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A comparison of phase imaging and quantitative susceptibility mapping in the imaging of multiple sclerosis lesions at ultrahigh field

Cronin, Matthew John; Wharton, Samuel; Al-Radaideh, Ali; Constantinescu, Chris; Evangelou, Nikos; Bowtell, Richard W.; Gowland, Penny A.

Authors

Matthew John Cronin

Samuel Wharton

Ali Al-Radaideh

Chris Constantinescu



Abstract

Objective

The aim of this study was to compare the use of high-resolution phase and QSM images acquired at ultra-high field in the investigation of multiple sclerosis (MS) lesions with peripheral rings, and to discuss their usefulness for drawing inferences about underlying tissue composition.

Materials and methods

Thirty-nine Subjects were scanned at 7 T, using 3D T2*-weighted and T1-weighted sequences. Phase images were then unwrapped and filtered, and quantitative susceptibility maps were generated using a thresholded k-space division method. Lesions were compared visually and using a 1D profiling algorithm.

Results

Lesions displaying peripheral rings in the phase images were identified in 10 of the 39 subjects. Dipolar projections were apparent in the phase images outside of the extent of several of these lesions; however, QSM images showed peripheral rings without such projections. These projections appeared ring-like in a small number of phase images where no ring was observed in QSM. 1D profiles of six well-isolated example lesions showed that QSM contrast corresponds more closely to the magnitude images than phase contrast.

Conclusions

Phase images contain dipolar projections, which confounds their use in the investigation of tissue composition in MS lesions. Quantitative susceptibility maps correct these projections, providing insight into the composition of MS lesions showing peripheral rings.

Citation

Cronin, M. J., Wharton, S., Al-Radaideh, A., Constantinescu, C., Evangelou, N., Bowtell, R. W., & Gowland, P. A. (2016). A comparison of phase imaging and quantitative susceptibility mapping in the imaging of multiple sclerosis lesions at ultrahigh field. Magnetic Resonance Materials in Physics, Biology and Medicine, 29(3), 543-557. https://doi.org/10.1007/s10334-016-0560-5

Journal Article Type Article
Acceptance Date Feb 26, 2016
Online Publication Date Apr 25, 2016
Publication Date 2016-06
Deposit Date Sep 27, 2016
Publicly Available Date Sep 27, 2016
Journal Magnetic Resonance Materials in Physics, Biology and Medicine
Print ISSN 0968-5243
Electronic ISSN 1352-8661
Publisher Springer Verlag
Peer Reviewed Peer Reviewed
Volume 29
Issue 3
Pages 543-557
DOI https://doi.org/10.1007/s10334-016-0560-5
Keywords Biophysics; Radiological and Ultrasound Technology; Radiology Nuclear Medicine and imaging
Public URL http://eprints.nottingham.ac.uk/id/eprint/37164
Publisher URL http://link.springer.com/article/10.1007/s10334-016-0560-5
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0





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