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Neural basis of reward anticipation and its genetic determinants

Jia, Tianye; Macare, Christine; Desrivières, Sylvane; Gonzalez, Dante A.; Tao, Chenyang; Ji, Xiaoxi; Ruggeri, Barbara; Nees, Frauke; Banaschewski, Tobias; Barker, Gareth J.; Bokde, Arun L. W.; Bromberg, Uli; Büchel, Christian; Conrod, Patricia J.; Dove, Rachel; Frouin, Vincent; Gallinat, Jürgen; Garavan, Hugh; Gowland, Penny A.; Heinz, Andreas; Ittermann, Bernd; Lathrop, Mark; Lemaitre, Hervé; Martinot, Jean-Luc; Paus, Tomáš; Pausova, Zdenka; Poline, Jean-Baptiste; Rietschel, Marcella; Robbins, Trevor; Smolka, Michael N.; Müller, Christian P.; Feng, Jianfeng; Rothenfluh, Adrian; Flor, Herta; Schumann, Gunter

Authors

Tianye Jia

Christine Macare

Sylvane Desrivières

Dante A. Gonzalez

Chenyang Tao

Xiaoxi Ji

Barbara Ruggeri

Frauke Nees

Tobias Banaschewski

Gareth J. Barker

Arun L. W. Bokde

Uli Bromberg

Christian Büchel

Patricia J. Conrod

Rachel Dove

Vincent Frouin

Jürgen Gallinat

Hugh Garavan

Penny A. Gowland

Andreas Heinz

Bernd Ittermann

Mark Lathrop

Hervé Lemaitre

Jean-Luc Martinot

Tomáš Paus

Zdenka Pausova

Jean-Baptiste Poline

Marcella Rietschel

Trevor Robbins

Michael N. Smolka

Christian P. Müller

Jianfeng Feng

Adrian Rothenfluh

Herta Flor

Gunter Schumann



Abstract

Dysfunctional reward processing is implicated in various mental disorders, including attention deficit hyperactivity disorder (ADHD) and addictions. Such impairments might involve different components of the reward process, including brain activity during reward anticipation. We examined brain nodes engaged by reward anticipation in 1,544 adolescents and identified a network containing a core striatal node and cortical nodes facilitating outcome prediction and response preparation. Distinct nodes and functional connections were preferentially associated with either adolescent hyperactivity or alcohol consumption, thus conveying specificity of reward processing to clinically relevant behavior. We observed associations between the striatal node, hyperactivity, and the vacuolar protein sorting-associated protein 4A (VPS4A) gene in humans, and the causal role of Vps4 for hyperactivity was validated in Drosophila. Our data provide a neurobehavioral model explaining the heterogeneity of reward-related behaviors and generate a hypothesis accounting for their enduring nature.

Journal Article Type Article
Publication Date Apr 5, 2016
Journal Proceedings of the National Academy of Sciences
Print ISSN 0027-8424
Electronic ISSN 1091-6490
Publisher National Academy of Sciences
Peer Reviewed Peer Reviewed
Volume 113
Issue 14
Pages 3879-3884
APA6 Citation Jia, T., Macare, C., Desrivières, S., Gonzalez, D. A., Tao, C., Ji, X., …Schumann, G. (2016). Neural basis of reward anticipation and its genetic determinants. Proceedings of the National Academy of Sciences, 113(14), 3879-3884. https://doi.org/10.1073/pnas.1503252113
DOI https://doi.org/10.1073/pnas.1503252113
Publisher URL http://www.pnas.org/content/113/14/3879
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf
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