Neural basis of reward anticipation and its genetic determinants

Jia, Tianye; Macare, Christine; Desrivi�res, Sylvane; Gonzalez, Dante A.; Tao, Chenyang; Ji, Xiaoxi; Ruggeri, Barbara; Nees, Frauke; Banaschewski, Tobias; Barker, Gareth J.; Bokde, Arun L. W.; Bromberg, Uli; B�chel, Christian; Conrod, Patricia J.; Dove, Rachel; Frouin, Vincent; Gallinat, J�rgen; Garavan, Hugh; Gowland, Penny A.; Heinz, Andreas; Ittermann, Bernd; Lathrop, Mark; Lemaitre, Herv�; Martinot, Jean-Luc; Paus, Tom�; Pausova, Zdenka; Poline, Jean-Baptiste; Rietschel, Marcella; Robbins, Trevor; Smolka, Michael N.; M�ller, Christian P.; Feng, Jianfeng; Rothenfluh, Adrian; Flor, Herta; Schumann, Gunter

Abstract

Dysfunctional reward processing is implicated in various mental disorders, including attention deficit hyperactivity disorder (ADHD) and addictions. Such impairments might involve different components of the reward process, including brain activity during reward anticipation. We examined brain nodes engaged by reward anticipation in 1,544 adolescents and identified a network containing a core striatal node and cortical nodes facilitating outcome prediction and response preparation. Distinct nodes and functional connections were preferentially associated with either adolescent hyperactivity or alcohol consumption, thus conveying specificity of reward processing to clinically relevant behavior. We observed associations between the striatal node, hyperactivity, and the vacuolar protein sorting-associated protein 4A (VPS4A) gene in humans, and the causal role of Vps4 for hyperactivity was validated in Drosophila. Our data provide a neurobehavioral model explaining the heterogeneity of reward-related behaviors and generate a hypothesis accounting for their enduring nature.

Citation

Jia, T., Macare, C., Desrivières, S., Gonzalez, D. A., Tao, C., Ji, X., Ruggeri, B., Nees, F., Banaschewski, T., Barker, G. J., Bokde, A. L. W., Bromberg, U., Büchel, C., Conrod, P. J., Dove, R., Frouin, V., Gallinat, J., Garavan, H., Gowland, P. A., Heinz, A., …Schumann, G. (2016). Neural basis of reward anticipation and its genetic determinants. Proceedings of the National Academy of Sciences, 113(14), 3879-3884. https://doi.org/10.1073/pnas.1503252113

• Journal Article Type: Article
• Acceptance Date: Feb 11, 2016
• Online Publication Date: Mar 21, 2016
• Publication Date: Apr 5, 2016
• Deposit Date: May 9, 2017
• Journal: Proceedings of the National Academy of Sciences
• Print ISSN: 0027-8424
• Electronic ISSN: 1091-6490
• Publisher: National Academy of Sciences
• Peer Reviewed: Peer Reviewed
• Volume: 113
• Issue: 14
• Pages: 3879-3884
• DOI: https://doi.org/10.1073/pnas.1503252113
• Public URL: https://nottingham-repository.worktribe.com/output/786394
• Publisher URL: http://www.pnas.org/content/113/14/3879
• Contract Date: May 9, 2017