Viral Vector Vaccines Against ASF: Problems and Prospectives

Ravilov, Rustam Kh; Rizvanov, Albert A.; Mingaleev, Danil N.; Galeeva, Antonina G.; Zakirova, Elena Yu; Shuralev, Eduard A.; Rutland, Catrin S.; Khammadov, Nail I.; Efimova, Marina A.

doi:10.3389/fvets.2022.830244

Viral Vector Vaccines Against ASF: Problems and Prospectives

Ravilov, Rustam Kh; Rizvanov, Albert A.; Mingaleev, Danil N.; Galeeva, Antonina G.; Zakirova, Elena Yu; Shuralev, Eduard A.; Rutland, Catrin S.; Khammadov, Nail I.; Efimova, Marina A.

Authors

Rustam Kh Ravilov

Albert A. Rizvanov

Danil N. Mingaleev

Antonina G. Galeeva

Elena Yu Zakirova

Eduard A. Shuralev

CATRIN RUTLAND CATRIN.RUTLAND@NOTTINGHAM.AC.UK
Associate Professor

Nail I. Khammadov

Marina A. Efimova

Abstract

African swine fever (ASF) is a highly contagious viral disease affecting pigs, with mortality rates a primary focus as they can reach up to 100%. The widespread and colossal economic losses from ASF have impacts on the development of animal husbandry practices in most countries within Africa, Asia, and Europe. Currently, a variety of approaches toward the development of vaccines against ASF are being employed. A promising new concept centered around more economical and time-consuming vaccine production is based on the use of viral vectors to deliver selected immunogens. This review discusses the results obtained from testing various viral vectors as carriers of targeted ASF virus genes. The safety and prospects of viral vectors, the possibilities around modulating cellular and humoral immune responses by choosing genes expressing immunodominant antigens, and the degree of protection in experimental animals from infection with a lethal dose of virulent ASF virus strains have been shown and discussed.

Journal Article Type	Article
Acceptance Date	Feb 11, 2022
Online Publication Date	Mar 11, 2022
Publication Date	Mar 11, 2022
Deposit Date	Apr 29, 2022
Publicly Available Date	Apr 29, 2022
Journal	Frontiers in Veterinary Science
Electronic ISSN	2297-1769
Publisher	Frontiers Media SA
Peer Reviewed	Peer Reviewed
Volume	9
Article Number	830244
DOI	https://doi.org/10.3389/fvets.2022.830244
Keywords	General Veterinary
Public URL	https://nottingham-repository.worktribe.com/output/7838772
Publisher URL	https://www.frontiersin.org/articles/10.3389/fvets.2022.830244/full