P. Nikolakopoulou
STAT3-Ser/Hes3 signaling: a new molecular component of the neuroendocrine system?
Nikolakopoulou, P.; Poser, S.W.; Masjkur, J.; Fernandez Rubin de Celis, M.; Toutouna, L.; Andoniadou, C.L.; McKay, R.D.; Chrousos, G.; Ehrhart-Bornstein, M.; Bornstein, S.R.; Androutsellis-Theotokis, A.
Authors
S.W. Poser
J. Masjkur
M. Fernandez Rubin de Celis
L. Toutouna
C.L. Andoniadou
R.D. McKay
G. Chrousos
M. Ehrhart-Bornstein
S.R. Bornstein
A. Androutsellis-Theotokis
Abstract
The endocrine system involves communication among different tissues in distinct organs, including the pancreas and components of the Hypothalamic- Pituitary-Adrenal Axis. The molecular mechanisms underlying these complex interactions are a subject of intense study as they may hold clues for the progression and treatment of a variety of metabolic and degenerative diseases. A plethora of signaling pathways, activated by hormones and other endocrine factors have been implicated in this communication. Recent advances in the stem cell field introduce a new level of complexity: adult progenitor cells appear to utilize distinct signaling pathways than the more mature cells in the tissue they co-reside. It is therefore important to elucidate the signal transduction requirements of adult progenitor cells in addition to those of mature cells. Recent evidence suggests that a common non-canonical signaling pathway regulates adult progenitors in several different tissues, rendering it as a potentially valuable starting point to explore their biology. The STAT3- Ser/Hes3 Signaling Axis was first identified as a major regulator of neural stem cells and, subsequently, cancer stem cells. In the endocrine/neuroendocrine system, this pathway operates on several levels, regulating other types of plastic cells: (a) it regulates pancreatic islet cell function and insulin release; (b) insulin in turn activates the pathway in broadly distributed neural progenitors and possibly also hypothalamic tanycytes, cells with important roles in the control of the adrenal gland; (c) adrenal progenitors themselves operate this pathway. The STAT3-Ser/Hes3 Signaling Axis therefore deserves additional research in the context of endocrinology.
Citation
Nikolakopoulou, P., Poser, S., Masjkur, J., Fernandez Rubin de Celis, M., Toutouna, L., Andoniadou, C., …Androutsellis-Theotokis, A. (2016). STAT3-Ser/Hes3 signaling: a new molecular component of the neuroendocrine system?. Hormone and Metabolic Research, 48(2), https://doi.org/10.1055/s-0041-111699
Journal Article Type | Article |
---|---|
Acceptance Date | Dec 16, 2015 |
Online Publication Date | Jan 19, 2016 |
Publication Date | Apr 30, 2016 |
Deposit Date | May 10, 2017 |
Journal | Hormone and Metabolic Research |
Print ISSN | 0018-5043 |
Electronic ISSN | 1439-4286 |
Publisher | Thieme Publishing |
Peer Reviewed | Peer Reviewed |
Volume | 48 |
Issue | 2 |
DOI | https://doi.org/10.1055/s-0041-111699 |
Keywords | STAT3, Hes3, stem cells |
Public URL | https://nottingham-repository.worktribe.com/output/783067 |
Publisher URL | https://doi.org/10.1055/s-0041-111699 |
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