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Long-term exposure to irinotecan reduces cell migration in glioma cells.

Al-Ghafari, Ayat B.; Punjaruk, Wiyada; Storer, L.C.D.; Carrier, D.J.; Hussein, D.; Coyle, Beth; Kerr, Ian D.


Ayat B. Al-Ghafari

Wiyada Punjaruk

L.C.D. Storer

D.J. Carrier

D. Hussein

Associate Professor

Ian D. Kerr


In spite of considerable research into the therapies for glioblastoma multiforme this tumour type remains very difficult to treat. As well as having a tendency to be inherently resistant to chemotherapy, glioblastoma multiforme also displays local invasion. Cell line studies have a continued and important role to play in understanding the mechanisms associated with both chemotherapy resistance and invasion. In the current study we have utilized the C6 glioma cell line to investigate the response to long-term, clinically relevant application of topoisomerase I and II inhibitors. Treatment with etoposide resulted in an increase in resistance to this topoisomerase II inhibitor. By contrast, the continuous exposure to a topoisomerase I inhibitor did not result in increased drug resistance, but was associated with a reduction in cell migration. This data supports further investigation of topoisomerase I inhibition as a means to inhibit glioma invasion without the development of parallel chemoresistance.


Al-Ghafari, A. B., Punjaruk, W., Storer, L., Carrier, D., Hussein, D., Coyle, B., & Kerr, I. D. (2016). Long-term exposure to irinotecan reduces cell migration in glioma cells. Journal of Neuro-Oncology, 127(3), 455-462.

Journal Article Type Article
Acceptance Date Jan 25, 2016
Online Publication Date Jan 30, 2016
Publication Date May 1, 2016
Deposit Date Jun 21, 2016
Publicly Available Date Jun 21, 2016
Journal Journal of Neuro-Oncology
Print ISSN 0167-594X
Electronic ISSN 1573-7373
Publisher Springer Verlag
Peer Reviewed Peer Reviewed
Volume 127
Issue 3
Pages 455-462
Keywords Glioma, Topoisomerase, Etoposide, Irinotecan, ABCB1, Invasion, Chemotherapy
Public URL
Publisher URL
Additional Information The final publication is available at Springer via


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