Synovial changes detected by ultrasound in people with knee osteoarthritis – a meta-analysis of observational studies

Sarmanov, Aliya; Hall, Michelle C.; Moses, Jonathan; Doherty, Michael; Zhang, Weiya

Abstract

© 2016 The Authors Objectives To examine the prevalence of synovial effusion, synovial hypertrophy and positive Doppler signal (DS) detected by ultrasound (US) in people with knee osteoarthritis (OA) and/or knee pain compared to that in the general population. Method A systematic literature search was undertaken in Medline, EMBASE, Allied and Complementary Medicine, PubMed Web of Science, and SCOPUS databases in May 2015. Frequencies of US abnormalities in people with knee OA/pain, in the general population or asymptomatic controls were pooled using the random effects model. Publication bias and heterogeneity between studies were examined. Results Twenty four studies in people with knee pain/OA and five studies of the general population or asymptomatic controls met the inclusion criteria. The pooled prevalence of US effusion, synovial hypertrophy and positive DS in people with knee OA/pain were 51.5% (95% CI 40.2 to 62.8), 41.5% (26.3–57.5) and 32.7% (8.34–63.24), respectively, which were higher than those in the general population or asymptomatic controls (19.9% (95%CI 7.8–35.3%), 14.5% (0–58.81), and 15.8 (3.08–35.36), respectively). People with knee OA (ACR criteria or radiographic OA) had greater prevalence of US abnormalities than people with knee pain (P=0.037, P=0.010 and P=0.009, respectively). Conclusions US detected effusion, synovial hypertrophy and DS are more common in people with knee OA/pain, compared to the general population. These abnormalities relate more to presence of OA structural changes than to pain.

Citation

Sarmanov, A., Hall, M. C., Moses, J., Doherty, M., & Zhang, W. (2016). Synovial changes detected by ultrasound in people with knee osteoarthritis – a meta-analysis of observational studies. Osteoarthritis and Cartilage, 24(8), 1376-1383. https://doi.org/10.1016/j.joca.2016.03.004

• Journal Article Type: Article
• Acceptance Date: Mar 3, 2016
• Online Publication Date: Mar 10, 2016
• Publication Date: Aug 1, 2016
• Deposit Date: Apr 19, 2016
• Publicly Available Date: Apr 19, 2016
• Journal: Osteoarthritis and Cartilage
• Print ISSN: 1063-4584
• Electronic ISSN: 1522-9653
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 24
• Issue: 8
• Pages: 1376-1383
• DOI: https://doi.org/10.1016/j.joca.2016.03.004
• Keywords: ultrasound; synovial; osteoarthritis; meta-analysis; synovitis
• Public URL: https://nottingham-repository.worktribe.com/output/780820
• Publisher URL: http://www.sciencedirect.com/science/article/pii/S106345841601061X
• Additional Information: This article is maintained by: Elsevier; Article Title: Synovial changes detected by ultrasound in people with knee osteoarthritis – a meta-analysis of observational studies; Journal Title: Osteoarthritis and Cartilage; CrossRef DOI link to publisher maintained version: https://doi.org/10.1016/j.joca.2016.03.004; Content Type: article; Copyright: © 2016 The Authors. Published by Elsevier Ltd on behalf of Osteoarthritis Research Society International.