Combinatorial Biomolecular Nanopatterning for High-Throughput Screening of Stem-Cell Behavior

Amin, Yacoub Y. I.; Runager, Kasper; Simoes, Fabio; Celiz, Adam; Taresco, Vincenzo; Rossi, Roberto; Enghild, Jan J.; Abildtrup, Lisbeth A.; Kraft, David C. E.; Sutherland, Duncan S.; Alexander, Morgan R.; Foss, Morten; Ogaki, Ryosuke

Abstract

© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. A novel combinatorial biomolecular nanopatterning method is reported, in which multiple biomolecular ligands can be patterned in multiple nanoscale dimensions on a single surface. The applicability of the combinatorial platform toward cell-biology applications is demonstrated by screening the adhesion behavior of a population of human dental pulp stem cell (hDPSC) on 64 combinations of nanopatterned extracellular matrix (ECM) proteins in parallel.

Citation

Amin, Y. Y. I., Runager, K., Simoes, F., Celiz, A., Taresco, V., Rossi, R., …Ogaki, R. (2016). Combinatorial Biomolecular Nanopatterning for High-Throughput Screening of Stem-Cell Behavior. Advanced Materials, 28(7), 1472-1476. https://doi.org/10.1002/adma.201504995

• Journal Article Type: Article
• Acceptance Date: Oct 1, 2015
• Online Publication Date: Dec 9, 2015
• Publication Date: Feb 17, 2016
• Deposit Date: Jul 18, 2016
• Publicly Available Date: Jul 18, 2016
• Journal: Advanced Materials
• Print ISSN: 0935-9648
• Electronic ISSN: 0935-9648
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 28
• Issue: 7
• Pages: 1472-1476
• DOI: https://doi.org/10.1002/adma.201504995
• Public URL: https://nottingham-repository.worktribe.com/output/776009
• Publisher URL: http://dx.doi.org/10.1002/adma.201504995
• Additional Information: "This is the peer reviewed version of the following article: Amin, Y. Y. I., Runager, K., Simoes, F., Celiz, A., Taresco, V., Rossi, R., Enghild, J. J., Abildtrup, L. A., Kraft, D. C. E., Sutherland, D. S., Alexander, M. R., Foss, M. and Ogaki, R. (2016), Combinatorial Biomolecular Nanopatterning for High-Throughput Screening of Stem-Cell Behavior. Adv. Mater., 28: 1472–1476. doi:10.1002/adma.201504995, which has been published in final form at https://doi.org/10.1002/adma.201504995. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving."