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Early life programming of health and disease: The long-term consequences of obesity in pregnancy

Langley-Evans, Simon C.

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Authors

Simon C. Langley-Evans



Abstract

The prevalence of overweight and obesity is rising in all parts of the world and, among young women, it presents a very clear danger during pregnancy. Women who are overweight or who gain excessive weight during pregnancy are at greater risk of complications in pregnancy and labour, and are more likely to lose their child to stillbirth or die themselves during pregnancy. This narrative review considers the evidence that, in addition to increasing risk of poor pregnancy outcomes, obesity has the capacity to programme foetuses to be at greater risk of cardiometabolic disorders later in life. An extensive body of evidence from prospective and retrospective cohorts, as well as record linkage studies, demonstrates associations of maternal obesity and/or gestational diabetes with cardiovascular disease, as well as type 1 and type 2 diabetes. Studies in animals suggest that these associations are underpinned by adaptations that occur in foetal life, which remodel the structures of major organs, including the brain, kidney and pancreas.

Citation

Langley-Evans, S. C. (2022). Early life programming of health and disease: The long-term consequences of obesity in pregnancy. Journal of Human Nutrition and Dietetics, 35(5), 816-832. https://doi.org/10.1111/jhn.13023

Journal Article Type Review
Acceptance Date Apr 6, 2022
Online Publication Date Apr 27, 2022
Publication Date 2022-10
Deposit Date Apr 7, 2022
Publicly Available Date Apr 28, 2023
Journal Journal of Human Nutrition and Dietetics
Print ISSN 0952-3871
Electronic ISSN 1365-277X
Peer Reviewed Peer Reviewed
Volume 35
Issue 5
Pages 816-832
DOI https://doi.org/10.1111/jhn.13023
Keywords Nutrition and Dietetics; Medicine (miscellaneous)
Public URL https://nottingham-repository.worktribe.com/output/7712013
Publisher URL https://onlinelibrary.wiley.com/doi/10.1111/jhn.13023

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