Perfluorooctane sulfonate concentrations in amniotic fluid, biomarkers of fetal Leydig cell function, and cryptorchidism and hypospadias in Danish boys (1980–1996)
Toft, Gunnar; Jönsson, Bo A.G.; Bonde, Jens Peter; Nørgaard-Pedersen, Bent; Hougaard, David M.; Cohen, Arieh; Lindh, Christian H.; Ivell, Richard; Anand-Ivell, Ravinder; Lindhard, Morten S.
Bo A.G. Jönsson
Jens Peter Bonde
David M. Hougaard
Christian H. Lindh
Richard Ivell firstname.lastname@example.org
RAVINDER ANAND-IVELL Ravinder.Anandemail@example.com
Morten S. Lindhard
Background: Exposure to perfluorooctane sulfonate (PFOS) may potentially disturb fetal Leydig cell hormone production and male genital development.
Objectives: We aimed to study the associations between levels of amniotic fluid PFOS, fetal steroid hormone, and insulin-like factor 3 (INSL3) and the prevalence of cryptorchidism and hypospadias.
Methods: Using the Danish National Patient Registry, we selected 270 cryptorchidism cases,75 hypospadias cases, and 300 controls with stored maternal amniotic fluid samples available in a Danish pregnancy-screening biobank (1980–1996). We used mass spectrometry to measure PFOS in amniotic fluid from 645 persons and steroid hormones in samples from 545 persons. INSL3 was measured by immunoassay from 475 persons. Associations between PFOS concentration in amniotic fluid, hormone levels, and genital malformations were assessed by confounder-adjusted linear and logistic regression.
Results: The highest tertile of PFOS exposure (> 1.4 ng/mL) in amniotic fluid was associated with a 40% (95% CI: –69, –11%) lower INSL3 level and an 18% (95% CI: 7, 29%) higher testosterone level compared with the lowest tertile (< 0.8 ng/mL). Amniotic fluid PFOS concentration was not associated with cryptorchidism or hypospadias.
Conclusions: Environmental PFOS exposure was associated with steroid hormone and INSL3 concentrations in amniotic fluid, but was not associated with cryptorchidism or hypospadias in our study population. Additional studies are needed to determine whether associations with fetal hormone levels may have long-term implications for reproductive health.
Toft, G., Jönsson, B. A., Bonde, J. P., Nørgaard-Pedersen, B., Hougaard, D. M., Cohen, A., …Lindhard, M. S. (2016). Perfluorooctane sulfonate concentrations in amniotic fluid, biomarkers of fetal Leydig cell function, and cryptorchidism and hypospadias in Danish boys (1980–1996). Environmental Health Perspectives, 124(1), https://doi.org/10.1289/ehp.1409288
|Journal Article Type||Article|
|Acceptance Date||Jun 1, 2015|
|Online Publication Date||Jun 5, 2015|
|Publication Date||Jan 1, 2016|
|Deposit Date||Mar 22, 2017|
|Publicly Available Date||Mar 22, 2017|
|Journal||Environmental Health Perspectives|
|Publisher||National Institute of Environmental Health Sciences|
|Peer Reviewed||Peer Reviewed|
|Keywords||Amniotic fluid, endocrine disruptors, phthalates|
|Copyright Statement||Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf|
|Additional Information||Reproduced with permission from Environmental Health Perspectives.|
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf
You might also like
Prepubertal nutrition alters Leydig cell functional capacity and timing of puberty
Insulin-like peptide 3 (INSL3) is a major regulator of female reproductive physiology
Testicular function and bone in young men with severe childhood-onset obesity.