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Methods for differentiating prion types in food-producing animals

Gough, Kevin C.; Rees, Helen C.; Ives, Sarah E.; Maddison, Ben C.

Authors

KEVIN GOUGH kevin.gough@nottingham.ac.uk
Professor of Biochemistry and Pathology

Helen C. Rees

Sarah E. Ives

Ben C. Maddison



Abstract

Prions are an enigma amongst infectious disease agents as they lack a genome yet confer specific pathologies thought to be dictated mainly, if not solely, by the conformation of the disease form of the prion protein (PrPSc). Prion diseases affect humans and animals, the latter including the food-producing ruminant species cattle, sheep, goats and deer. Importantly, it has been shown that the disease agent of bovine spongiform encephalopathy (BSE) is zoonotic, causing variant Creutzfeldt Jakob disease (vCJD) in humans. Current diagnostic tests can distinguish different prion types and in food- producing animals these focus on the differentiation of BSE from the non-zoonotic agents. Whilst BSE cases are now rare, atypical forms of both scrapie and BSE have been reported, as well as two types of chronic wasting disease (CWD) in cervids. Typing of animal prion isolates remains an important aspect of prion diagnosis and is now becoming more focused on identifying the range of prion types that are present in food-producing animals and also developing tests that can screen for emerging, novel prion diseases. Here, we review prion typing methodologies in light of current and emerging prion types in food-producing animals.

Citation

Gough, K. C., Rees, H. C., Ives, S. E., & Maddison, B. C. (2015). Methods for differentiating prion types in food-producing animals. Biology, 4(4), https://doi.org/10.3390/biology4040785

Journal Article Type Article
Acceptance Date Nov 4, 2015
Publication Date Nov 13, 2015
Deposit Date Nov 7, 2016
Publicly Available Date Nov 7, 2016
Journal Biology
Electronic ISSN 2079-7737
Publisher MDPI
Peer Reviewed Peer Reviewed
Volume 4
Issue 4
DOI https://doi.org/10.3390/biology4040785
Keywords Prion; Transmissible spongiform encephalopathy; Scrapie; BSE; CWD; Strain typing
Public URL http://eprints.nottingham.ac.uk/id/eprint/38512
Publisher URL http://www.mdpi.com/2079-7737/4/4/785
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0





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