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Buprenorphine for neuropathic pain in adults

Wiffen, Philip J.; Derry, Sheena; Moore, R. Andrew; Stannard, Cathy; Aldington, Dominic; Cole, Peter; Knaggs, Roger

Authors

Philip J. Wiffen

Sheena Derry

R. Andrew Moore

Cathy Stannard

Dominic Aldington

Peter Cole



Abstract

BACKGROUND

Opioid drugs, including buprenorphine, are commonly used to treat neuropathic pain, and are considered effective by some professionals. Most reviews have examined all opioids together. This review sought evidence specifically for buprenorphine, at any dose, and by any route of administration. Other opioids are considered in separate reviews.

OBJECTIVES

To assess the analgesic efficacy of buprenorphine for chronic neuropathic pain in adults, and the adverse events associated with its use in clinical trials.

SEARCH METHODS

We searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, and EMBASE from inception to 11 June 2015, together with reference lists of retrieved papers and reviews, and two online study registries.

SELECTION CRITERIA

We included randomised, double-blind studies of two weeks' duration or longer, comparing any oral dose or formulation of buprenorphine with placebo or another active treatment in chronic neuropathic pain.

DATA COLLECTION AND ANALYSIS

Two review authors independently searched for studies, extracted efficacy and adverse event data, and examined issues of study quality. We did not carry out any pooled analyses.

MAIN RESULTS

Searches identified 10 published studies, and one study with results in ClinicalTrials.gov. None of these 11 studies satisfied our inclusion criteria, and so we included no studies in the review.

AUTHORS' CONCLUSIONS

There was insufficient evidence to support or refute the suggestion that buprenorphine has any efficacy in any neuropathic pain condition.

Journal Article Type Article
Publication Date Sep 30, 2015
Journal Cochrane Database of Systematic Reviews
Electronic ISSN 1469-493X
Publisher Cochrane Collaboration
Peer Reviewed Peer Reviewed
Issue 9
Article Number CD011603
APA6 Citation Wiffen, P. J., Derry, S., Moore, R. A., Stannard, C., Aldington, D., Cole, P., & Knaggs, R. (2015). Buprenorphine for neuropathic pain in adults. Cochrane Database of Systematic Reviews, https://doi.org/10.1002/14651858.CD011603.pub2
DOI https://doi.org/10.1002/14651858.CD011603.pub2
Publisher URL http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD011603.pub2/abstract
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf

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Buprenorphine_NeuP.pdf (293 Kb)
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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





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