Rui Ponte Costa
Unified pre- and postsynaptic long-term plasticity enables reliable and flexible learning
Costa, Rui Ponte; Froemke, Robert C.; Sj�str�m, P. Jesper; van Rossum, Mark C.W.
Authors
Robert C. Froemke
P. Jesper Sj�str�m
Mark C.W. van Rossum
Abstract
Although it is well known that long-term synaptic plasticity can be expressed both pre- and postsynaptically, the functional consequences of this arrangement have remained elusive. We show that spike-timing-dependent plasticity with both pre- and postsynaptic expression develops receptive fields with reduced variability and improved discriminability compared to postsynaptic plasticity alone. These long-term modifications in receptive field statistics match recent sensory perception experiments. Moreover, learning with this form of plasticity leaves a hidden postsynaptic memory trace that enables fast relearning of previously stored information, providing a cellular substrate for memory savings. Our results reveal essential roles for presynaptic plasticity that are missed when only postsynaptic expression of long-term plasticity is considered, and suggest an experience-dependent distribution of pre- and postsynaptic strength changes.
Citation
Costa, R. P., Froemke, R. C., Sjöström, P. J., & van Rossum, M. C. (2015). Unified pre- and postsynaptic long-term plasticity enables reliable and flexible learning. eLife, 4, 1-16. https://doi.org/10.7554/eLife.09457
Journal Article Type | Article |
---|---|
Acceptance Date | Aug 25, 2015 |
Online Publication Date | Aug 26, 2015 |
Publication Date | Aug 26, 2015 |
Deposit Date | Feb 7, 2018 |
Publicly Available Date | Feb 7, 2018 |
Journal | eLife |
Electronic ISSN | 2050-084X |
Publisher | eLife Sciences Publications |
Peer Reviewed | Peer Reviewed |
Volume | 4 |
Article Number | e09457 |
Pages | 1-16 |
DOI | https://doi.org/10.7554/eLife.09457 |
Public URL | https://nottingham-repository.worktribe.com/output/758457 |
Publisher URL | https://elifesciences.org/articles/09457 |
Contract Date | Feb 7, 2018 |
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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0
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