Lukas Solanka
Noise promotes independent control of gamma oscillations and grid firing within recurrent attractor networks
Solanka, Lukas; van Rossum, Mark C.W.; Nolan, Matthew F.
Authors
Mark C.W. van Rossum
Matthew F. Nolan
Abstract
Neural computations underlying cognitive functions require calibration of the strength of excitatory and inhibitory synaptic connections and are associated with modulation of gamma frequency oscillations in network activity. However, principles relating gamma oscillations, synaptic strength and circuit computations are unclear. We address this in attractor network models that account for grid firing and theta-nested gamma oscillations in the medial entorhinal cortex. We show that moderate intrinsic noise massively increases the range of synaptic strengths supporting gamma oscillations and grid computation. With moderate noise, variation in excitatory or inhibitory synaptic strength tunes the amplitude and frequency of gamma activity without disrupting grid firing. This beneficial role for noise results from disruption of epileptic-like network states. Thus, moderate noise promotes independent control of multiplexed firing rate- and gamma-based computational mechanisms. Our results have implications for tuning of normal circuit function and for disorders associated with changes in gamma oscillations and synaptic strength.
Citation
Solanka, L., van Rossum, M. C., & Nolan, M. F. (in press). Noise promotes independent control of gamma oscillations and grid firing within recurrent attractor networks. eLife, 4, Article e06444. https://doi.org/10.7554/eLife.06444
Journal Article Type | Article |
---|---|
Acceptance Date | Jul 4, 2015 |
Online Publication Date | Jul 6, 2015 |
Deposit Date | Feb 8, 2018 |
Publicly Available Date | Mar 29, 2024 |
Journal | eLife |
Electronic ISSN | 2050-084X |
Publisher | eLife Sciences Publications |
Peer Reviewed | Peer Reviewed |
Volume | 4 |
Article Number | e06444 |
DOI | https://doi.org/10.7554/eLife.06444 |
Public URL | https://nottingham-repository.worktribe.com/output/757546 |
Publisher URL | https://elifesciences.org/articles/06444 |
Files
elife-06444-v2.pdf
(4.8 Mb)
PDF
Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0
You might also like
Competitive plasticity to reduce the energetic costs of learning
(2023)
Working Paper
Estimating the energy requirements for long term memory formation
(2023)
Working Paper
Weight dependence in BCM leads to adjustable synaptic competition
(2022)
Journal Article
Electro-physiology Models of Cells with Spherical Geometry with Non-conducting Center
(2020)
Journal Article
Downloadable Citations
About Repository@Nottingham
Administrator e-mail: digital-library-support@nottingham.ac.uk
This application uses the following open-source libraries:
SheetJS Community Edition
Apache License Version 2.0 (http://www.apache.org/licenses/)
PDF.js
Apache License Version 2.0 (http://www.apache.org/licenses/)
Font Awesome
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
Powered by Worktribe © 2024
Advanced Search