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Spontaneous action potentials and neural coding in unmyelinated axons

O'Donnell, Cian; van Rossum, Mark C.W.

Authors

Cian O'Donnell

Mark C.W. van Rossum



Abstract

The voltage-gated Na and K channels in neurons are responsible for action potential generation. Because ion channels open and close in a stochastic fashion, spontaneous (ectopic) action potentials can result even in the absence of stimulation. While spontaneous action potentials have been studied in detail in single-compartment models, studies on spatially extended processes have been limited. The simulations and analysis presented here show that spontaneous rate in unmyelinated axon depends nonmonotonically on the length of the axon, that the spontaneous activity has sub-Poisson statistics, and that neural coding can be hampered by the spontaneous spikes by reducing the probability of transmitting the first spike in a train.

Journal Article Type Article
Publication Date Apr 30, 2015
Journal Neural Computation
Print ISSN 0899-7667
Electronic ISSN 1530-888X
Publisher Massachusetts Institute of Technology Press
Peer Reviewed Peer Reviewed
Volume 27
Issue 4
APA6 Citation O'Donnell, C., & van Rossum, M. C. (2015). Spontaneous action potentials and neural coding in unmyelinated axons. Neural Computation, 27(4), https://doi.org/10.1162/NECO_a_00705
DOI https://doi.org/10.1162/NECO_a_00705
Publisher URL https://www.mitpressjournals.org/doi/10.1162/NECO_a_00705
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





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