Enantioselective copper-catalyzed reductive coupling of vinylazaarenes with N-Boc aldimines

Choi, Bonnie; Saxena, Aakarsh; Smith, Joshua J.; Churchill, Gwydion H.; Lam, Hon Wai

Abstract

The diastereo- and enantioselective reductive coupling of vinylazaarenes with N-Boc aldimines is described. The reactions proceed using chiral copper–bisphosphine complexes in the presence of TMDS as a hydride source to give reductive coupling products in moderate to high enantioselectivities.

Citation

Choi, B., Saxena, A., Smith, J. J., Churchill, G. H., & Lam, H. W. (2015). Enantioselective copper-catalyzed reductive coupling of vinylazaarenes with N-Boc aldimines. SYNLETT, 26(3), https://doi.org/10.1055/s-0034-1379548

• Journal Article Type: Article
• Acceptance Date: Oct 22, 2014
• Publication Date: Feb 28, 2015
• Deposit Date: Jun 8, 2017
• Publicly Available Date: Jun 8, 2017
• Journal: Synlett
• Print ISSN: 0936-5214
• Electronic ISSN: 1437-2096
• Publisher: Thieme Publishing
• Peer Reviewed: Peer Reviewed
• Volume: 26
• Issue: 3
• DOI: https://doi.org/10.1055/s-0034-1379548
• Keywords: Asymmetric catalysis, Copper, Enantioselectivity, Imines, Vinylazaarenes
• Public URL: https://nottingham-repository.worktribe.com/output/744163
• Publisher URL: https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0034-1379548
• Additional Information: © 2015 Georg Thieme Verlag KG
• Contract Date: Jun 8, 2017