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Enantioselective copper-catalyzed reductive coupling of vinylazaarenes with N-Boc aldimines

Choi, Bonnie; Saxena, Aakarsh; Smith, Joshua J.; Churchill, Gwydion H.; Lam, Hon Wai

Authors

Bonnie Choi

Aakarsh Saxena

Joshua J. Smith

Gwydion H. Churchill

HON LAM Hon.Lam@nottingham.ac.uk
Professor of Sustainable Chemistry



Abstract

The diastereo- and enantioselective reductive coupling of vinylazaarenes with N-Boc aldimines is described. The reactions proceed using chiral copper–bisphosphine complexes in the presence of TMDS as a hydride source to give reductive coupling products in moderate to high enantioselectivities.

Journal Article Type Article
Publication Date Feb 28, 2015
Journal Synlett
Print ISSN 0936-5214
Electronic ISSN 1437-2096
Publisher Thieme Publishing
Peer Reviewed Peer Reviewed
Volume 26
Issue 3
APA6 Citation Choi, B., Saxena, A., Smith, J. J., Churchill, G. H., & Lam, H. W. (2015). Enantioselective copper-catalyzed reductive coupling of vinylazaarenes with N-Boc aldimines. SYNLETT, 26(3), https://doi.org/10.1055/s-0034-1379548
DOI https://doi.org/10.1055/s-0034-1379548
Keywords Asymmetric catalysis, Copper, Enantioselectivity, Imines, Vinylazaarenes
Publisher URL https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0034-1379548
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf
Additional Information © 2015 Georg Thieme Verlag KG

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





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