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Enantioselective copper-catalyzed reductive coupling of vinylazaarenes with N-Boc aldimines

Choi, Bonnie; Saxena, Aakarsh; Smith, Joshua J.; Churchill, Gwydion H.; Lam, Hon Wai

Authors

Bonnie Choi

Aakarsh Saxena

Joshua J. Smith

Gwydion H. Churchill

HON LAM Hon.Lam@nottingham.ac.uk
Professor of Sustainable Chemistry



Abstract

The diastereo- and enantioselective reductive coupling of vinylazaarenes with N-Boc aldimines is described. The reactions proceed using chiral copper–bisphosphine complexes in the presence of TMDS as a hydride source to give reductive coupling products in moderate to high enantioselectivities.

Citation

Choi, B., Saxena, A., Smith, J. J., Churchill, G. H., & Lam, H. W. (2015). Enantioselective copper-catalyzed reductive coupling of vinylazaarenes with N-Boc aldimines. SYNLETT, 26(3), https://doi.org/10.1055/s-0034-1379548

Journal Article Type Article
Acceptance Date Oct 22, 2014
Publication Date Feb 28, 2015
Deposit Date Jun 8, 2017
Publicly Available Date Jun 8, 2017
Journal Synlett
Print ISSN 0936-5214
Electronic ISSN 1437-2096
Publisher Thieme Publishing
Peer Reviewed Peer Reviewed
Volume 26
Issue 3
DOI https://doi.org/10.1055/s-0034-1379548
Keywords Asymmetric catalysis, Copper, Enantioselectivity, Imines, Vinylazaarenes
Public URL http://eprints.nottingham.ac.uk/id/eprint/43480
Publisher URL https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0034-1379548
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf
Additional Information © 2015 Georg Thieme Verlag KG

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





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