George Procopiou
Two-directional synthesis and biological evaluation of alkaloid 5-epi-cis-275B′
Procopiou, George; Aggarwal, Pooja; Newton, Annabella F.; Richards, David; Mellor, Ian R.; Harbottle, Gareth; Stockman, Robert A.
Authors
Pooja Aggarwal
Annabella F. Newton
David Richards
IAN MELLOR IAN.MELLOR@NOTTINGHAM.AC.UK
Assistant Professor
Gareth Harbottle
ROBERT STOCKMAN robert.stockman@nottingham.ac.uk
Professor of Organic Chemistry
Abstract
© 2014 The Royal Society of Chemistry. The first total synthesis of myrmicine ant alkaloid 5-epi-cis-275B′ (4) is presented. A tandem cyclisation established the entire core of the structure in a single transformation as well as the required 2,5-anti stereochemistry. Two-directional synthesis was used to furnish the cyclisation precursor 2, as in each of the subsequent steps towards the natural product. The first electrophysiology studies for 4 (against nicotinic acetylcholine receptors) were also conducted, finding modest inhibition of current.
Citation
Procopiou, G., Aggarwal, P., Newton, A. F., Richards, D., Mellor, I. R., Harbottle, G., & Stockman, R. A. (2014). Two-directional synthesis and biological evaluation of alkaloid 5-epi-cis-275B′. Chemical Communications, 50(97), 15355-15357. https://doi.org/10.1039/c4cc07287a
Journal Article Type | Article |
---|---|
Acceptance Date | Oct 15, 2014 |
Online Publication Date | Oct 15, 2014 |
Publication Date | Oct 15, 2014 |
Deposit Date | Jan 26, 2017 |
Publicly Available Date | Jan 26, 2017 |
Journal | Chemical Communications |
Print ISSN | 1359-7345 |
Electronic ISSN | 1364-548X |
Publisher | Royal Society of Chemistry |
Peer Reviewed | Peer Reviewed |
Volume | 50 |
Issue | 97 |
Pages | 15355-15357 |
DOI | https://doi.org/10.1039/c4cc07287a |
Public URL | https://nottingham-repository.worktribe.com/output/738196 |
Publisher URL | http://pubs.rsc.org/en/Content/ArticleLanding/2014/CC/C4CC07287A#!divAbstract |
Additional Information | : This document is CrossCheck deposited; : Supplementary Information; : George Procopiou (ResearcherID); : Pooja Aggarwal (ORCID); : Pooja Aggarwal (ResearcherID); : The Royal Society of Chemistry has an exclusive publication licence for this journal; OPEN ACCESS: The accepted version of this article will be made freely available after a 12 month embargo period; : Received 15 September 2014; Accepted 15 October 2014; Accepted Manuscript published 15 October 2014; Advance Article published 28 October 2014; Version of Record published 11 November 2014 |
Contract Date | Jan 26, 2017 |
Files
ChemComm 2014.pdf
(473 Kb)
PDF
Downloadable Citations
About Repository@Nottingham
Administrator e-mail: discovery-access-systems@nottingham.ac.uk
This application uses the following open-source libraries:
SheetJS Community Edition
Apache License Version 2.0 (http://www.apache.org/licenses/)
PDF.js
Apache License Version 2.0 (http://www.apache.org/licenses/)
Font Awesome
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
Powered by Worktribe © 2024
Advanced Search