Systematic analysis of the contributions of stochastic voltage gated channels to neuronal noise

O'Donnell, Cian; van Rossum, Mark C.W.

doi:10.3389/fncom.2014.00105

Systematic analysis of the contributions of stochastic voltage gated channels to neuronal noise

O'Donnell, Cian; van Rossum, Mark C.W.

Authors

Cian O'Donnell

Mark C.W. van Rossum

Abstract

Electrical signaling in neurons is mediated by the opening and closing of large numbers of individual ion channels. The ion channels' state transitions are stochastic and introduce fluctuations in the macroscopic current through ion channel populations. This creates an unavoidable source of intrinsic electrical noise for the neuron, leading to fluctuations in the membrane potential and spontaneous spikes. While this effect is well known, the impact of channel noise on single neuron dynamics remains poorly understood. Most results are based on numerical simulations. There is no agreement, even in theoretical studies, on which ion channel type is the dominant noise source, nor how inclusion of additional ion channel types affects voltage noise. Here we describe a framework to calculate voltage noise directly from an arbitrary set of ion channel models, and discuss how this can be use to estimate spontaneous spike rates.

Citation

O'Donnell, C., & van Rossum, M. C. (2014). Systematic analysis of the contributions of stochastic voltage gated channels to neuronal noise. Frontiers in Computational Neuroscience, 8, https://doi.org/10.3389/fncom.2014.00105

Journal Article Type	Article
Acceptance Date	Aug 18, 2014
Publication Date	Sep 4, 2014
Deposit Date	Feb 8, 2018
Publicly Available Date	Feb 8, 2018
Journal	Frontiers in Computational Neuroscience
Electronic ISSN	1662-5188
Publisher	Frontiers Media
Peer Reviewed	Peer Reviewed
Volume	8
DOI	https://doi.org/10.3389/fncom.2014.00105
Keywords	channel noise, voltage-gated ion channels, Hodgkin–Huxley, spontaneous firing, simulation
Public URL	https://nottingham-repository.worktribe.com/output/737040
Publisher URL	https://www.frontiersin.org/articles/10.3389/fncom.2014.00105/full