The incidence and prevalence of systemic lupus erythematosus in the UK, 1999–2012

Rees, Frances; Doherty, Michael; Grainge, Matthew J.; Davenport, Graham; Lanyon, Peter; Zhang, Weiya

Abstract

Objectives: To estimate the incidence and prevalence of systemic lupus erythematosus (SLE) in the UK over the period 1999–2012.

Methods: A retrospective cohort study using the Clinical Practice Research Datalink (CPRD). The incidence was calculated per 100 000 person-years and the prevalence was calculated per 100 000 people for the period 1999–2012 and stratified by year, age group, gender, region and ethnicity. Three definitions of SLE were explored: (1) systemic lupus, (2) a fully comprehensive definition of lupus including cutaneous only lupus and (3) requiring supporting evidence of SLE in the medical record.

Results: Using our primary definition of SLE, the incidence during the study period was 4.91/100 000 person-years (95% CI 4.73 to 5.09), with an annual 1.8% decline (p

• Journal Article Type: Article
• Acceptance Date: Sep 13, 2014
• Online Publication Date: Sep 29, 2014
• Deposit Date: Aug 15, 2016
• Publicly Available Date: Aug 15, 2016
• Journal: Annals of the Rheumatic Diseases
• Print ISSN: 0003-4967
• Electronic ISSN: 1468-2060
• Publisher: BMJ Publishing Group
• Peer Reviewed: Peer Reviewed
• Volume: 75
• Issue: 1
• DOI: https://doi.org/10.1136/annrheumdis-2014-206334
• Keywords: Autoimmune Diseases, Epidemiology, systemic lupus erythematosus
• Public URL: https://nottingham-repository.worktribe.com/output/735079
• Publisher URL: http://ard.bmj.com/content/75/1/136