Skip to main content

Research Repository

Advanced Search

Systems Analysis of Auxin Transport in the Arabidopsis Root Apex

Band, Leah R.; Wells, Darren M.; Fozard, John A.; Ghetiu, Teodor; French, Andrew P.; Pound, Michael P.; Wilson, Michael H.; Yu, Lei; Li, Wenda; Hijazi, Hussein I.; Oh, Jaesung; Pearce, Simon P.; Perez-Amador, Miguel A.; Yun, Jeonga; Kramer, Eric; Alonso, Jose M.; Godin, Christophe; Vernoux, Teva; Hodgman, T. Charlie; Pridmore, Tony P.; Swarup, Ranjan; King, John R.; Bennett, Malcolm J.

Systems Analysis of Auxin Transport in the Arabidopsis Root Apex Thumbnail


Professor of Mathematical Biology

Principal Research Fellow

John A. Fozard

Teodor Ghetiu

Profile Image

Professor of Computer Science

Lei Yu

Wenda Li

Hussein I. Hijazi

Jaesung Oh

Simon P. Pearce

Miguel A. Perez-Amador

Jeonga Yun

Eric Kramer

Jose M. Alonso

Christophe Godin

Teva Vernoux

T. Charlie Hodgman

Professor of Computer Science

Professor of Theoretical Mechanics


Auxin is a key regulator of plant growth and development. Within the root tip, auxin distribution plays a crucial role specifying developmental zones and coordinating tropic responses. Determining how the organ-scale auxin pattern is regulated at the cellular scale is essential to understanding how these processes are controlled. In this study, we developed an auxin transport model based on actual root cell geometries and carrier subcellular localizations. We tested model predictions using the DII-VENUS auxin sensor in conjunction with state-of-the-art segmentation tools. Our study revealed that auxin efflux carriers alone cannot create the pattern of auxin distribution at the root tip and that AUX1/LAX influx carriers are also required. We observed that AUX1 in lateral root cap (LRC) and elongating epidermal cells greatly enhance auxin’s shootward flux, with this flux being predominantly through the LRC, entering the epidermal cells only as they enter the elongation zone. We conclude that the nonpolar AUX1/LAX influx carriers control which tissues have high auxin levels, whereas the polar PIN carriers control the direction of auxin transport within these tissues.

Journal Article Type Article
Acceptance Date Feb 14, 2014
Online Publication Date Mar 14, 2014
Publication Date Mar 14, 2014
Deposit Date Oct 18, 2016
Publicly Available Date Oct 18, 2016
Journal Plant Cell
Print ISSN 1040-4651
Electronic ISSN 1532-298X
Publisher American Society of Plant Biologists
Peer Reviewed Peer Reviewed
Volume 26
Issue 3
Pages 862-875
Public URL
Publisher URL


You might also like

Downloadable Citations