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Nitric oxide sensing in plants is mediated by proteolytic control of Group VII ERF transcription factors

Gibbs, Daniel J.; Md Isa, Nurulhikma; Movahedi, Mahsa; Lozano-Juste, Jorge; Mendiondo, Guillermina M.; Berckhan, Sophie; Mar�n-de la Rosa, Nora; Vicente Conde, Jorge; Sousa Correia, Cristina; Pearce, Simon P.; Bassel, George W.; Hamali, Bulut; Talloji, Prabhavathi; Tom�, Daniel F.A.; Coego, Alberto; Beynon, Jim; Alabad�, David; Bachmair, Andreas; Le�n, Jos�; Gray, Julie E.; Theodoulou, Frederica L.; Holdsworth, Michael J.

Nitric oxide sensing in plants is mediated by proteolytic control of Group VII ERF transcription factors Thumbnail


Authors

Daniel J. Gibbs

Nurulhikma Md Isa

Mahsa Movahedi

Jorge Lozano-Juste

Sophie Berckhan

Nora Mar�n-de la Rosa

Jorge Vicente Conde

Cristina Sousa Correia

Simon P. Pearce

George W. Bassel

Bulut Hamali

Prabhavathi Talloji

Daniel F.A. Tom�

Alberto Coego

Jim Beynon

David Alabad�

Andreas Bachmair

Jos� Le�n

Julie E. Gray

Frederica L. Theodoulou



Abstract

Nitric oxide (NO) is an important signaling compound in prokaryotes and eukaryotes. In plants, NO regulates critical developmental transitions and stress responses. Here, we identify a mechanism for NO sensing that coordinates responses throughout development based on targeted degradation of plant-specific transcriptional regulators, the group VII ethylene response factors (ERFs). We show that the N-end rule pathway of targeted proteolysis targets these proteins for destruction in the presence of NO, and we establish them as critical regulators of diverse NO-regulated processes, including seed germination, stomatal closure, and hypocotyl elongation. Furthermore, we define the molecular mechanism for NO control of germination and crosstalk with abscisic acid (ABA) signaling through ERF-regulated expression of ABSCISIC ACID INSENSITIVE5 (ABI5). Our work demonstrates how NO sensing is integrated across multiple physiological processes by direct modulation of transcription factor stability and identifies group VII ERFs as central hubs for the perception of gaseous signals in plants.

Citation

Gibbs, D. J., Md Isa, N., Movahedi, M., Lozano-Juste, J., Mendiondo, G. M., Berckhan, S., …Holdsworth, M. J. (2014). Nitric oxide sensing in plants is mediated by proteolytic control of Group VII ERF transcription factors. Molecular Cell, 53(3), https://doi.org/10.1016/j.molcel.2013.12.020

Journal Article Type Article
Acceptance Date Dec 13, 2013
Online Publication Date Jan 23, 2014
Publication Date Feb 6, 2014
Deposit Date Jan 24, 2017
Publicly Available Date Mar 28, 2024
Journal Molecular Cell
Print ISSN 1097-2765
Electronic ISSN 1097-4164
Publisher Cell Press
Peer Reviewed Peer Reviewed
Volume 53
Issue 3
DOI https://doi.org/10.1016/j.molcel.2013.12.020
Public URL https://nottingham-repository.worktribe.com/output/723449
Publisher URL http://www.sciencedirect.com/science/article/pii/S1097276513009301

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