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Novel MRI tests of orocecal transit time and whole gut transit time: studies in normal subjects

Chaddock, G.; Lam, C.; Hoad, C.L.; Costigan, C.; Cox, E. F.; Placidi, E.; Thexton, I.; Wright, J.; Blackshaw, P. E.; Perkins, A. C.; Marciani, L.; Gowland, Penny A.; Spiller, Robin C.

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G. Chaddock

C. Lam

Senior Research Fellow

C. Costigan

E. F. Cox

E. Placidi

I. Thexton

J. Wright

P. E. Blackshaw

A. C. Perkins

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Professor of Gastrointestinal Imaging

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Professor of Gastroenterology


Background: Colonic transit tests are used to manage patients with Functional Gastrointestinal Disorders. Some tests used expose patients to ionizing radiation. The aim of this study was to compare novel magnetic resonance imaging (MRI) tests for measuring orocecal transit time (OCTT) and whole gut transit time (WGT), which also provide data on colonic volumes. Methods: 21 healthy volunteers participated. Study 1: OCTT was determined from the arrival of the head of a meal into the cecum using MRI and the Lactose Ureide breath test (LUBT), performed concurrently. Study 2: WGT was assessed using novel MRI marker capsules and radio-opaque markers (ROMs), taken on the same morning. Studies were repeated 1 week later. Key Results: OCTT measured using MRI and LUBT was 225 min (IQR 180-270) and 225 min (IQR 165-278), respectively, correlation rs = 0.28 (ns). WGT measured using MRI marker capsules and ROMs was 28 h (IQR 4-50) and 31 h ± 3 (SEM), respectively, correlation rs = 0.85 (p < 0.0001). Repeatability assessed using the intraclass correlation coefficient (ICC) was 0.45 (p = 0.017) and 0.35 (p = 0.058) for MRI and LUBT OCTT tests. Better repeatability was observed for the WGT tests, ICC being 0.61 for the MRI marker capsules (p = 0.001) and 0.69 for the ROM method (p < 0.001) respectively. Conclusions & Inferences: The MRI WGT method is simple, convenient, does not use X-ray and compares well with the widely used ROM method. Both OCTT measurements showed modest reproducibility and the MRI method showed modest inter-observer agreement. & Sons Ltd.


Chaddock, G., Lam, C., Hoad, C., Costigan, C., Cox, E. F., Placidi, E., …Spiller, R. C. (2014). Novel MRI tests of orocecal transit time and whole gut transit time: studies in normal subjects. Neurogastroenterology and Motility, 26(2), 205-214.

Journal Article Type Article
Acceptance Date Sep 23, 2013
Online Publication Date Oct 25, 2013
Publication Date 2014-02
Deposit Date Apr 22, 2014
Publicly Available Date Apr 22, 2014
Journal Neurogastroenterology & Motility
Print ISSN 1350-1925
Electronic ISSN 1365-2982
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 26
Issue 2
Pages 205-214
Public URL
Publisher URL


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