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Comparative safety of artemether-lumefantrine and other artemisinin-based combinations in children: a systematic review

Egunsola, Oluwaseun; Oshikoya, Kazeem A.

Authors

Oluwaseun Egunsola

Kazeem A. Oshikoya

Abstract

Background
The purpose of the study was to compare the safety of artemether-lumefantrine (AL) with other artemisinin-based combinations in children.

Methods
A search of EMBASE (from 1974 to April 2013), MEDLINE (from 1946 to April 2013) and the Cochrane library of registered controlled trials for randomized controlled trials (RCTs) which compared AL with other artemisinin-based combinations was done. Only studies involving children ≤ 17 years old in which safety of AL was an outcome measure were included.

Results
Four thousand, seven hundred and twenty six adverse events (AEs) were recorded in 6,000 patients receiving AL. Common AEs (≥1/100 and

Journal Article Type Article
Publication Date Nov 1, 2013
Journal Malaria Journal
Electronic ISSN 1475-2875
Publisher Humana Press
Peer Reviewed Peer Reviewed
Volume 12
Issue Novemb
Article Number 8
Institution Citation Egunsola, O., & Oshikoya, K. A. (2013). Comparative safety of artemether-lumefantrine and other artemisinin-based combinations in children: a systematic review. Malaria Journal, 12(Novemb), doi:10.1186/1475-2875-12-385
DOI https://doi.org/10.1186/1475-2875-12-385
Keywords Artemether-lumefantrine, Adverse event, Paediatrics, Children, Safety
Publisher URL http://www.malariajournal.com/content/12/1/385
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0




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