Comparative safety of artemether-lumefantrine and other artemisinin-based combinations in children: a systematic review
Egunsola, Oluwaseun; Oshikoya, Kazeem A.
Kazeem A. Oshikoya
The purpose of the study was to compare the safety of artemether-lumefantrine (AL) with other artemisinin-based combinations in children.
A search of EMBASE (from 1974 to April 2013), MEDLINE (from 1946 to April 2013) and the Cochrane library of registered controlled trials for randomized controlled trials (RCTs) which compared AL with other artemisinin-based combinations was done. Only studies involving children ≤ 17 years old in which safety of AL was an outcome measure were included.
Four thousand, seven hundred and twenty six adverse events (AEs) were recorded in 6,000 patients receiving AL. Common AEs (≥1/100 and
Egunsola, O., & Oshikoya, K. A. (2013). Comparative safety of artemether-lumefantrine and other artemisinin-based combinations in children: a systematic review. Malaria Journal, 12(Novemb), doi:10.1186/1475-2875-12-385
|Journal Article Type||Article|
|Publication Date||Nov 1, 2013|
|Deposit Date||Apr 22, 2014|
|Publicly Available Date||Apr 22, 2014|
|Peer Reviewed||Peer Reviewed|
|Keywords||Artemether-lumefantrine, Adverse event, Paediatrics, Children, Safety|
|Copyright Statement||Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0|
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0