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All-cause mortality in people with cirrhosis compared with the general population: a population-based cohort study

Fleming, Kate M.; Aithal, Guruprasad P.; Card, Tim R.; West, Joe

Authors

Kate M. Fleming

Guruprasad P. Aithal

Tim R. Card

JOE WEST JOE.WEST@NOTTINGHAM.AC.UK
Professor of Epidemiology



Abstract

Background: Mortality due to cirrhosis has tripled over the last 30 years in the UK. However, we lack adequate, contemporary, population-based estimates of the excess mortality patients who are at risk compared with the general population.
Aim: To determine the overall survival in patients with cirrhosis compared with the general population taking into account the effects of severity and aetiology of disease and comorbidity.
Methods: In a cohort study, we identified 4537 people with cirrhosis and a control cohort of 44 403 patients, matched by age, sex and general practice from the UK General Practice Research Database between June 1987 and April 2002.
Results: Patients with compensated cirrhosis had a nearly five-fold [hazard ratio (HR) 4.7, 95% confidence interval (CI) 4.4–5.0] increased risk of death, while those with decompensated cirrhosis had a near 10-fold (HR 9.7, 95% CI 8.9–10.6) increased risk compared with the general population. Alcoholic cirrhosis conferred a worse prognosis than non-alcohol-related cirrhosis both in the first year following diagnosis and subsequently.
Conclusion: Having a diagnosis of cirrhosis confers a substantial increased mortality risk compared with the general population, even for those with compensated disease, with 5-year survival between that seen for breast and colorectal cancer.

Citation

Fleming, K. M., Aithal, G. P., Card, T. R., & West, J. (2012). All-cause mortality in people with cirrhosis compared with the general population: a population-based cohort study. Liver International, 32(1), https://doi.org/10.1111/j.1478-3231.2011.02517.x

Journal Article Type Article
Acceptance Date Mar 2, 2011
Online Publication Date Apr 6, 2011
Publication Date Jan 3, 2012
Deposit Date Aug 24, 2017
Publicly Available Date Aug 24, 2017
Journal Liver International
Print ISSN 1478-3223
Electronic ISSN 1478-3231
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 32
Issue 1
DOI https://doi.org/10.1111/j.1478-3231.2011.02517.x
Public URL http://eprints.nottingham.ac.uk/id/eprint/45119
Publisher URL http://onlinelibrary.wiley.com/doi/10.1111/j.1478-3231.2011.02517.x/abstract
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





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