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Total loss of MHC class I is an independent indicator of good prognosis in breast cancer

Madjd, Zahra; Spendlove, Ian; Pinder, Sarah E.; Ellis, Ian O.; Durrant, Lindy G.


Zahra Madjd

Sarah E. Pinder

Ian O. Ellis

Lindy G. Durrant


Tumours can be recognised by CTL and NK cells. CTL recognition depends on expression of MHC Class I loaded with peptides from tumour antigens. In contrast, loss of MHC Class I results in NK activation. In our study a large set of samples from patients with primary operable invasive breast cancer was evaluated for the expression of MHC Class I heavy and light by immunohistochemical staining of 439 breast carcinomas in a tissue microarray. Forty-seven percent (206 of 439) of breast carcinomas were considered negative for HLA Class I heavy chain (HC10), whereas lack of anti-?2m-antibody staining was observed in 39% (167 of 424) of tumours, with only 3% of the ?2m-negative tumours expressing detectable HLA Class I heavy chain. Correlation with patient outcome showed direct relationship between patient survival and HLA-negative phenotype (log rank = 0.004). A positive relationship was found between the intensity of expression of MHC Class I light and heavy chains expression and histological grade of invasive tumour (p < 0.001) and Nottingham Prognostic Index (p < 0.001). To investigate whether HLA Class I heavy and light chains expression had independent prognostic significance, Cox multivariate regression analysis, including the parameters of tumour size, lymph node stage, grade and intensity of HC10 and anti-?2m staining, was carried out. In our analysis, lymph node stage (p < 0.001), tumour grade (p = 0.005) and intensity of MHC Class I light and heavy chains expression were shown to be independent prognostic factors predictive of overall survival (p-values HC10 = 0.047 and ?2m = 0.018).


Madjd, Z., Spendlove, I., Pinder, S. E., Ellis, I. O., & Durrant, L. G. (2005). Total loss of MHC class I is an independent indicator of good prognosis in breast cancer. International Journal of Cancer, 117(2),

Journal Article Type Article
Publication Date Nov 1, 2005
Deposit Date May 9, 2014
Publicly Available Date May 9, 2014
Journal International Journal of Cancer
Print ISSN 0020-7136
Electronic ISSN 0020-7136
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 117
Issue 2
Keywords Breast tissue microarray, HC10, Prognostic factor, MHC Class I, Immunohistochemistry
Public URL
Publisher URL;jsessionid=0F2D2BA7158A645CEAA0FEC990F1DD0E.f02t04


Ian_Ellis-total_Loss.pdf (638 Kb)

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