Total loss of MHC class I is an independent indicator of good prognosis in breast cancer
Madjd, Zahra; Spendlove, Ian; Pinder, Sarah E.; Ellis, Ian O.; Durrant, Lindy G.
IAN SPENDLOVE IAN.SPENDLOVE@NOTTINGHAM.AC.UK
Sarah E. Pinder
Ian O. Ellis
Lindy G. Durrant
Tumours can be recognised by CTL and NK cells. CTL recognition depends on expression of MHC Class I loaded with peptides from tumour antigens. In contrast, loss of MHC Class I results in NK activation. In our study a large set of samples from patients with primary operable invasive breast cancer was evaluated for the expression of MHC Class I heavy and light by immunohistochemical staining of 439 breast carcinomas in a tissue microarray. Forty-seven percent (206 of 439) of breast carcinomas were considered negative for HLA Class I heavy chain (HC10), whereas lack of anti-?2m-antibody staining was observed in 39% (167 of 424) of tumours, with only 3% of the ?2m-negative tumours expressing detectable HLA Class I heavy chain. Correlation with patient outcome showed direct relationship between patient survival and HLA-negative phenotype (log rank = 0.004). A positive relationship was found between the intensity of expression of MHC Class I light and heavy chains expression and histological grade of invasive tumour (p < 0.001) and Nottingham Prognostic Index (p < 0.001). To investigate whether HLA Class I heavy and light chains expression had independent prognostic significance, Cox multivariate regression analysis, including the parameters of tumour size, lymph node stage, grade and intensity of HC10 and anti-?2m staining, was carried out. In our analysis, lymph node stage (p < 0.001), tumour grade (p = 0.005) and intensity of MHC Class I light and heavy chains expression were shown to be independent prognostic factors predictive of overall survival (p-values HC10 = 0.047 and ?2m = 0.018).
Madjd, Z., Spendlove, I., Pinder, S. E., Ellis, I. O., & Durrant, L. G. (2005). Total loss of MHC class I is an independent indicator of good prognosis in breast cancer. International Journal of Cancer, 117(2), https://doi.org/10.1002/ijc.21163
|Journal Article Type||Article|
|Publication Date||Nov 1, 2005|
|Deposit Date||May 9, 2014|
|Publicly Available Date||May 9, 2014|
|Journal||International Journal of Cancer|
|Peer Reviewed||Peer Reviewed|
|Keywords||Breast tissue microarray, HC10, Prognostic factor, MHC Class I, Immunohistochemistry|
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc/4.0