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Airway clearance and exercise for people with cystic fibrosis: Balancing longevity with life

Rowbotham, Nicola J.; Daniels, Tracey E.

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Nicola J. Rowbotham

Tracey E. Daniels


Airway clearance has been an integral part of cystic fibrosis (CF) care for almost as long as CF has been identified as a condition. From diagnosis as a neonate through to end-of-life care, airway clearance is an everyday aspect of life, adding a considerable treatment burden to the lives of people with CF. There are many different techniques used for airway clearance which have evolved over time with an aim to improve effectiveness, support adherence and, more recently, to consider the impact of burden. A popular thought is whether airway clearance could be replaced by exercise. With new precision therapies in the form of CFTR modulators available, the CF landscape is rapidly changing, raising the question of whether certain treatments are needed at all. Depending on factors such as CFTR mutation, age, and pre-existing lung damage before starting a CFTR modulator, individuals with CF may need different levels of intensity and type of maintenance treatment. Precision medicine is likely to lead to the need for increased precision and individualized management around other maintenance therapies such as airway clearance.

Journal Article Type Article
Acceptance Date Oct 18, 2021
Online Publication Date Oct 21, 2021
Publication Date 2022-02
Deposit Date Nov 4, 2021
Publicly Available Date Oct 22, 2022
Journal Pediatric Pulmonology
Print ISSN 8755-6863
Electronic ISSN 1099-0496
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 57
Issue S1
Pages S50-S59
Keywords Pulmonary and Respiratory Medicine; Pediatrics, Perinatology, and Child Health
Public URL
Publisher URL
Additional Information This is the peer reviewed version of the following article: Rowbotham, NJ, Daniels, TE. Airway clearance and exercise for people with cystic fibrosis: Balancing longevity with life. Pediatric Pulmonology. 2021; 1- 10, which has been published in final form at This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.


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