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JMM Profile: Carbapenems: a broad-spectrum antibiotic

Armstrong, Tom; Fenn, Samuel Jacob; Hardie, Kim R.

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Authors

Tom Armstrong

Samuel Jacob Fenn



Abstract

Carbapenems are potent members of the β-lactam family that inhibit bacterial cell-wall biosynthesis inhibitors . They are highly effective against Gram-negative and Gram-positive drug-resistant infections . As such, carbapenems are typically reserved as an antibiotic of last resort. The WHO lists meropenem as an essential medicine. Nausea and vomiting are reported in ≤20% of carbapenem recipients, with 1.5% suffering seizures. Enzymatic hydrolysis of the β-lactam ring is the main driver of clinical resistance. These enzymes can be classified as Class A, B and D. Classes A and D are serine β-lactamases, whereas Class B rely on metal-mediated hydrolysis, typically through zinc.

Citation

Armstrong, T., Fenn, S. J., & Hardie, K. R. (2021). JMM Profile: Carbapenems: a broad-spectrum antibiotic. Journal of Medical Microbiology, 70(12), Article 001462. https://doi.org/10.1099/jmm.0.001462

Journal Article Type Article
Acceptance Date Oct 18, 2021
Online Publication Date Dec 10, 2021
Publication Date Dec 10, 2021
Deposit Date Nov 4, 2021
Publicly Available Date Dec 10, 2021
Journal Journal of Medical Microbiology
Print ISSN 0022-2615
Electronic ISSN 1473-5644
Publisher Microbiology Society
Peer Reviewed Peer Reviewed
Volume 70
Issue 12
Article Number 001462
DOI https://doi.org/10.1099/jmm.0.001462
Public URL https://nottingham-repository.worktribe.com/output/6611017
Publisher URL https://www.microbiologyresearch.org/content/journal/jmm/10.1099/jmm.0.001462

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