Tom Armstrong
JMM Profile: Carbapenems: a broad-spectrum antibiotic
Armstrong, Tom; Fenn, Samuel Jacob; Hardie, Kim R.
Authors
Samuel Jacob Fenn
Professor KIM HARDIE KIM.HARDIE@NOTTINGHAM.AC.UK
PROFESSOR OF BACTERIAL PATHOGENESIS
Abstract
Carbapenems are potent members of the β-lactam family that inhibit bacterial cell-wall biosynthesis inhibitors . They are highly effective against Gram-negative and Gram-positive drug-resistant infections . As such, carbapenems are typically reserved as an antibiotic of last resort. The WHO lists meropenem as an essential medicine. Nausea and vomiting are reported in ≤20% of carbapenem recipients, with 1.5% suffering seizures. Enzymatic hydrolysis of the β-lactam ring is the main driver of clinical resistance. These enzymes can be classified as Class A, B and D. Classes A and D are serine β-lactamases, whereas Class B rely on metal-mediated hydrolysis, typically through zinc.
Citation
Armstrong, T., Fenn, S. J., & Hardie, K. R. (2021). JMM Profile: Carbapenems: a broad-spectrum antibiotic. Journal of Medical Microbiology, 70(12), Article 001462. https://doi.org/10.1099/jmm.0.001462
Journal Article Type | Article |
---|---|
Acceptance Date | Oct 18, 2021 |
Online Publication Date | Dec 10, 2021 |
Publication Date | Dec 10, 2021 |
Deposit Date | Nov 4, 2021 |
Publicly Available Date | Dec 10, 2021 |
Journal | Journal of Medical Microbiology |
Print ISSN | 0022-2615 |
Electronic ISSN | 1473-5644 |
Publisher | Microbiology Society |
Peer Reviewed | Peer Reviewed |
Volume | 70 |
Issue | 12 |
Article Number | 001462 |
DOI | https://doi.org/10.1099/jmm.0.001462 |
Public URL | https://nottingham-repository.worktribe.com/output/6611017 |
Publisher URL | https://www.microbiologyresearch.org/content/journal/jmm/10.1099/jmm.0.001462 |
Files
Antimicrobial Profile
(2.8 Mb)
PDF
Publisher Licence URL
https://creativecommons.org/licenses/by/4.0/
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