Patient-reported outcomes in adults with type 1 diabetes in global real-world clinical practice: The SAGE study

Wilmot, Emma G.; Close, Kelly L.; Jurišić‐Eržen, Dubravka; Bruttomesso, Daniela; Ampudia‐Blasco, F. Javier; Bosnyak, Zsolt; Roborel de Climens, Aude; Bigot, Grégory; Peters, Anne L.; Renard, Eric; Berard, Lori; Calliari, Luis Eduardo; Seufert, Jochen

Abstract

Aims
To conduct a secondary analysis of the SAGE study to evaluate the association between glycaemic control and patient-reported outcomes (PROs), in adults with type 1 diabetes (T1DM) across different age groups and regions.

Materials and methods
SAGE was a multinational, cross-sectional, observational study in adults with T1DM. Data were collected at a single visit, analysed according to predefined age groups (26-44, 45-64, and ≥65 years), and reported across different regions. PRO questionnaires were applied to assess hypoglycaemia fear (Hypoglycemia Fear Survey-II), diabetes-related distress (Problem Areas In Diabetes questionnaire), insulin treatment satisfaction (Insulin Treatment Satisfaction Questionnaire), and diabetes-specific quality of life (QoL; Audit of Diabetes-Dependent Quality of Life). Multivariable analysis was performed to evaluate the relationship between glycated haemoglobin (HbA1c) target achievement (<7% and individualised targets) with PRO scores.

Results
The PRO scores showed relatively low levels of diabetes-related emotional distress and fear of hypoglycaemia, moderate to high treatment satisfaction, and low diabetes-related impact on QoL. Results were generally comparable across age groups with some regional variability. Achievement of the HbA1c <7% target was associated with less worry about hypoglycaemia, lower diabetes-related emotional distress, higher insulin treatment satisfaction, and higher QoL. Achievement of individualised HbA1c targets was associated with lower diabetes-related emotional distress and higher insulin treatment satisfaction.

Conclusions
Better glycaemic control was most closely associated with low emotional distress due to diabetes and high patient-reported insulin treatment satisfaction.

Citation

Wilmot, E. G., Close, K. L., Jurišić‐Eržen, D., Bruttomesso, D., Ampudia‐Blasco, F. J., Bosnyak, Z., …Seufert, J. (2021). Patient-reported outcomes in adults with type 1 diabetes in global real-world clinical practice: The SAGE study. Diabetes, Obesity and Metabolism, 23(8), 1892-1901. https://doi.org/10.1111/dom.14416

• Journal Article Type: Article
• Acceptance Date: Apr 26, 2021
• Online Publication Date: Jun 14, 2021
• Publication Date: 2021-08
• Deposit Date: Jun 15, 2021
• Publicly Available Date: Jun 15, 2021
• Journal: Diabetes, Obesity and Metabolism
• Print ISSN: 1462-8902
• Electronic ISSN: 1463-1326
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 23
• Issue: 8
• Pages: 1892-1901
• DOI: https://doi.org/10.1111/dom.14416
• Keywords: Internal Medicine; Endocrinology, Diabetes and Metabolism; Endocrinology
• Public URL: https://nottingham-repository.worktribe.com/output/5686091
• Publisher URL: https://dom-pubs.onlinelibrary.wiley.com/doi/10.1111/dom.14416