Tianye Jia
Neural network involving medial orbitofrontal cortex and dorsal periaqueductal gray regulation in human alcohol abuse
Jia, Tianye; Xie, Chao; Banaschewski, Tobias; Barker, Gareth J.; Bokde, Arun L. W.; B�chel, Christian; Quinlan, Erin Burke; Desrivi�res, Sylvane; Flor, Herta; Grigis, Antoine; Garavan, Hugh; Gowland, Penny; Heinz, Andreas; Ittermann, Bernd; Martinot, Jean-Luc; Martinot, Marie-Laure Paill�re; Nees, Frauke; Orfanos, Dimitri Papadopoulos; Poustka, Luise; Fr�hner, Juliane H.; Smolka, Michael N.; Walter, Henrik; Whelan, Robert; Schumann, Gunter; Robbins, Trevor W.; Feng, Jianfeng; IMAGEN Consortium
Authors
Chao Xie
Tobias Banaschewski
Gareth J. Barker
Arun L. W. Bokde
Christian B�chel
Erin Burke Quinlan
Sylvane Desrivi�res
Herta Flor
Antoine Grigis
Hugh Garavan
Professor PENNY GOWLAND PENNY.GOWLAND@NOTTINGHAM.AC.UK
Professor of Physics
Andreas Heinz
Bernd Ittermann
Jean-Luc Martinot
Marie-Laure Paill�re Martinot
Frauke Nees
Dimitri Papadopoulos Orfanos
Luise Poustka
Juliane H. Fr�hner
Michael N. Smolka
Henrik Walter
Robert Whelan
Gunter Schumann
Trevor W. Robbins
Jianfeng Feng
IMAGEN Consortium
Abstract
Prompted by recent evidence of neural circuitry in rodent models, functional magnetic resonance imaging and functional connectivity analyses were conducted for a large adolescent population at two ages, together with alcohol abuse measures, to characterize a neural network that may underlie the onset of alcoholism. A network centered on the medial orbitofrontal cortex (mOFC), as well as including the dorsal periaqueductal gray (dPAG), central nucleus of the amygdala, and nucleus accumbens, was identified, consistent with the rodent models, with evidence of both inhibitory and excitatory coregulation by the mOFC over the dPAG. Furthermore, significant relationships were detected between raised baseline excitatory coregulation in this network and impulsivity measures, supporting a role for negative urgency in alcohol dependence.
Citation
Jia, T., Xie, C., Banaschewski, T., Barker, G. J., Bokde, A. L. W., Büchel, C., …IMAGEN Consortium. (2021). Neural network involving medial orbitofrontal cortex and dorsal periaqueductal gray regulation in human alcohol abuse. Science Advances, 7(6), 1-10. https://doi.org/10.1126/sciadv.abd4074
Journal Article Type | Article |
---|---|
Acceptance Date | Feb 3, 2021 |
Online Publication Date | Feb 3, 2021 |
Publication Date | 2021-02 |
Deposit Date | Jun 18, 2021 |
Publicly Available Date | Jun 18, 2021 |
Journal | Science Advances |
Electronic ISSN | 2375-2548 |
Publisher | American Association for the Advancement of Science |
Peer Reviewed | Peer Reviewed |
Volume | 7 |
Issue | 6 |
Article Number | eabd4074 |
Pages | 1-10 |
DOI | https://doi.org/10.1126/sciadv.abd4074 |
Public URL | https://nottingham-repository.worktribe.com/output/5294135 |
Publisher URL | https://advances.sciencemag.org/content/7/6/eabd4074 |
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