Ionic Permeability and Currents in the Lens

Donaldson, P. J.; Webb, K. F.

Abstract

© 2010 Elsevier Ltd. All rights reserved. It has been proposed that in the absence of a blood supply the lens operates an internal microcirculation system. In this system spatially distinct differences in the membrane transport properties of the lens surface relative to the inner lens fiber cells generate a circulating current that drives fluid flow. This extracellular flow of water convects nutrients toward the deeper lying fiber cells, while the intracellular flow removes wastes and creates a well-stirred intracellular compartment. This system also regulates the ionic composition of inner fiber cells, thereby maintaining their steady-state volume, a necessary requirement for the maintenance of overall lens transparency.

Citation

Donaldson, P. J., & Webb, K. F. (2010). Ionic Permeability and Currents in the Lens. In D. A. Dartt (Ed.), Encyclopedia of the Eye (477-486). Elsevier. https://doi.org/10.1016/B978-0-12-374203-2.00032-4

• Online Publication Date: Jul 12, 2010
• Publication Date: 2010
• Deposit Date: Apr 20, 2024
• Publisher: Elsevier
• Pages: 477-486
• Book Title: Encyclopedia of the Eye
• ISBN: 9780123742032
• DOI: https://doi.org/10.1016/B978-0-12-374203-2.00032-4
• Public URL: https://nottingham-repository.worktribe.com/output/4831759
• Publisher URL: https://www.sciencedirect.com/science/article/abs/pii/B9780123742032000324?via%3Dihub