27-year time trends in dementia incidence in Europe and the US: the Alzheimer Cohorts Consortium

Wolters, Frank J.; Chibnik, Lori B.; Waziry, Reem; Anderson, Roy; Berr, Claudine; Beiser, Alexa; Bis, Joshua C.; Blacker, Deborah; Bos, Daniel; Brayne, Carol; Dartigues, Jean-Fran�ois; Darweesh, Sirwan K.L.; Davis-Plourde, Kendra L; de Wolf, Frank; Debette, Stephanie; Dufouil, Carole; Fornage, Myriam; Goudsmit, Jaap; Grasset, Leslie; Gudnason, Vilmundur; Hadjichrysanthou, Christoforos; Helmer, Catherine; Arfan Ikram, M.; Ikram, M. Kamran; Joas, Erik; Kern, Silke; Kuller, Lewis H.; Launer, Lenore; Lopez, Oscar; Matthews, Fiona E.; McRae-McKee, Kevin; Meirelles, Osorio; Mosley, Thomas H.; Pase, Matthew P.; Psaty, Bruce M.; Satizabal, Claudia L; Seshadri, Sudha; Skoog, Ingmar; Stephan, Blossom C.M.; Wetterberg, Hanna; Wong, Mei Mei; Zettergren, Anna; Hofman, Albert

Abstract

Objective To determine changes in the incidence of dementia between 1988 and 2015.

Methods This analysis was performed in aggregated data from individuals >65 years of age in 7 population-based cohort studies in the United States and Europe from the Alzheimer Cohort Consortium. First, we calculated age- and sex-specific incidence rates for all-cause dementia, and then defined nonoverlapping 5-year epochs within each study to determine trends in incidence. Estimates of change per 10-year interval were pooled and results are presented combined and stratified by sex.

Results Of 49,202 individuals, 4,253 (8.6%) developed dementia. The incidence rate of dementia increased with age, similarly for women and men, ranging from about 4 per 1,000 person-years in individuals aged 65–69 years to 65 per 1,000 person-years for those aged 85–89 years. The incidence rate of dementia declined by 13% per calendar decade (95% confidence interval [CI], 7%–19%), consistently across studies, and somewhat more pronouncedly in men than in women (24% [95% CI 14%–32%] vs 8% [0%–15%]).

Conclusion The incidence rate of dementia in Europe and North America has declined by 13% per decade over the past 25 years, consistently across studies. Incidence is similar for men and women, although declines were somewhat more profound in men. These observations call for sustained efforts to finding the causes for this decline, as well as determining their validity in geographically and ethnically diverse populations.

Citation

Wolters, F. J., Chibnik, L. B., Waziry, R., Anderson, R., Berr, C., Beiser, A., Bis, J. C., Blacker, D., Bos, D., Brayne, C., Dartigues, J.-F., Darweesh, S. K., Davis-Plourde, K. L., de Wolf, F., Debette, S., Dufouil, C., Fornage, M., Goudsmit, J., Grasset, L., Gudnason, V., …Hofman, A. (2020). 27-year time trends in dementia incidence in Europe and the US: the Alzheimer Cohorts Consortium. Neurology, 95(5), https://doi.org/10.1212/wnl.0000000000010022

• Journal Article Type: Article
• Acceptance Date: Jan 31, 2020
• Online Publication Date: Jul 1, 2020
• Publication Date: Jul 1, 2020
• Deposit Date: Jun 18, 2020
• Publicly Available Date: Jul 16, 2020
• Journal: Neurology
• Print ISSN: 0028-3878
• Electronic ISSN: 1526-632X
• Publisher: American Academy of Neurology
• Peer Reviewed: Peer Reviewed
• Volume: 95
• Issue: 5
• DOI: https://doi.org/10.1212/wnl.0000000000010022
• Keywords: Clinical Neurology
• Public URL: https://nottingham-repository.worktribe.com/output/4673084
• Publisher URL: https://n.neurology.org/content/95/5/e519