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Thioredoxin system protein expression is associated with poor clinical outcome in adult and paediatric gliomas and medulloblastomas

Martin, Stewart; Yao, Anqi; Storr, Sarah J; Al-Hadyan, Khaled; Rahman, Ruman; Smith, Stuart; Grundy, Richard; Paine, Simon

Thioredoxin system protein expression is associated with poor clinical outcome in adult and paediatric gliomas and medulloblastomas Thumbnail


Authors

STEWART MARTIN STEWART.MARTIN@NOTTINGHAM.AC.UK
Professor of Cancer and Radiation Biology

Anqi Yao

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SARAH STORR sarah.storr@nottingham.ac.uk
Assistant Professor

Khaled Al-Hadyan

STUART SMITH stuart.smith@nottingham.ac.uk
Clinical Associate Professor

RICHARD GRUNDY richard.grundy@nottingham.ac.uk
Professor of Paediatric Neuro-Oncology

Simon Paine



Abstract

The thioredoxin (Trx) system is an important enzyme family that regulates cellular redox homeostasis. Protein expression of Trx system family members has been assessed in various cancers and linked to various clinicopathological variables, disease progression, treatment response and survival outcomes but information is lacking in brain tumours. Expression of the system was therefore examined, by immunohistochemistry in different brain tumour types, adult and paediatric cases, to determine if expression was of importance to clinical outcome. Trx system proteins were expressed, to variable levels, across all brain tumour types with significant variations in expression between different tumour types/grades/regions. High Trx reductase (TrxR) expression was linked to worse prognosis across all cohorts. High cytoplasmic TrxR expression was significantly associated with adverse overall survival (OS) in adult glioblastoma (P=0.027) and paediatric low-grade glioma (LGG) patients (P=0.012). High expression of nuclear TrxR, cytoplasmic and nuclear Trx, and Trxinteracting protein (TxNIP) was associated with improved OS in paediatric LGGs (P=0.031, P

Citation

Martin, S., Yao, A., Storr, S. J., Al-Hadyan, K., Rahman, R., Smith, S., …Paine, S. (2020). Thioredoxin system protein expression is associated with poor clinical outcome in adult and paediatric gliomas and medulloblastomas. Molecular Neurobiology, 57(7), 2889–2901. https://doi.org/10.1007/s12035-020-01928-z

Journal Article Type Article
Acceptance Date May 1, 2020
Online Publication Date May 16, 2020
Publication Date May 16, 2020
Deposit Date May 7, 2020
Publicly Available Date Mar 29, 2024
Journal Molecular Neurobiology
Print ISSN 0893-7648
Electronic ISSN 1559-1182
Publisher Springer Verlag
Peer Reviewed Peer Reviewed
Volume 57
Issue 7
Pages 2889–2901
DOI https://doi.org/10.1007/s12035-020-01928-z
Keywords Thioredoxin; Thioredoxin Reductase; glioblastoma; Low-grade glioma; High-grade glioma; Medulloblastoma
Public URL https://nottingham-repository.worktribe.com/output/4389172
Publisher URL https://link.springer.com/article/10.1007/s12035-020-01928-z

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