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Metal-based imaging agents: progress towards interrogating neurodegenerative disease

Sedgwick, Adam C.; Brewster, James T.; Harvey, Peter; Iovan, Diana A.; Smith, Graham; He, Xiao-Peng; Tian, He; Sessler, Jonathan L.; James, Tony D.

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Authors

Adam C. Sedgwick

James T. Brewster

Diana A. Iovan

Graham Smith

Xiao-Peng He

He Tian

Jonathan L. Sessler

Tony D. James



Abstract

Central nervous system (CNS) neurodegeneration is defined by a complex series of pathological processes that ultimately lead to death. The precise etiology of these disorders remains unknown. Recent efforts show that a mechanistic understanding of the malfunctions underpinning disease progression will prove requisite in developing new treatments and cures. Transition metals and lanthanide ions display unique characteristics (i.e., magnetism, radioactivity, and luminescence), often with biological relevance, allowing for direct application in CNS focused imaging modalities. These techniques include positron emission tomography (PET), single-photon emission computed tomography (SPECT), magnetic resonance imaging (MRI), and luminescent-based imaging (LumI). In this Tutorial Review, we have aimed to highlight the various metal-based imaging techniques developed in the effort to understand the pathophysiological processes associated with neurodegeneration. Each section has been divided so as to include an introduction to the particular imaging technique in question. This is then followed by a summary of key demonstrations that have enabled visualization of a specific neuropathological biomarker. These strategies have either exploited the high binding affinity of a receptor for its corresponding biomarker or a specific molecular transformation caused by a target species, all of which produce a concomitant change in diagnostic signal. Advantages and disadvantages of each method with perspectives on the utility of molecular imaging agents for understanding the complexities of neurodegenerative disease are discussed.

Citation

Sedgwick, A. C., Brewster, J. T., Harvey, P., Iovan, D. A., Smith, G., He, X.-P., …James, T. D. (2020). Metal-based imaging agents: progress towards interrogating neurodegenerative disease. Chemical Society Reviews, 2020(10), 2886-2915. https://doi.org/10.1039/c8cs00986d

Journal Article Type Article
Acceptance Date Mar 30, 2020
Online Publication Date Mar 30, 2020
Publication Date May 21, 2020
Deposit Date Jul 6, 2020
Publicly Available Date Jul 8, 2020
Journal Chemical Society Reviews
Print ISSN 0306-0012
Electronic ISSN 1460-4744
Publisher Royal Society of Chemistry
Peer Reviewed Peer Reviewed
Volume 2020
Issue 10
Pages 2886-2915
DOI https://doi.org/10.1039/c8cs00986d
Public URL https://nottingham-repository.worktribe.com/output/4248968
Publisher URL https://pubs.rsc.org/en/content/articlelanding/2020/CS/C8CS00986D#!divAbstract
Additional Information : This document is Similarity Check deposited; : Adam C. Sedgwick (ORCID); : James T. Brewster (ORCID); : Peter Harvey (ORCID); : Peter Harvey (ResearcherID); : Diana A. Iovan (ORCID); : Graham Smith (ORCID); : Xiao-Peng He (ORCID); : He Tian (ORCID); : Jonathan L. Sessler (ORCID); : Tony D. James (ORCID); : Single-blind; : Received 9 December 2019; Advance Article published 30 March 2020

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