Age?related decrements in cortical gyrification: Evidence from an accelerated longitudinal dataset

Madan, Christopher R.

Abstract

Cortical gyrification has been found to decrease due to aging, but thus far this has only been examined in cross‐sectional samples. Interestingly, the topography of these age‐related differences in gyrification follows a distinct gradient along the cortex relative to age effects on cortical thickness, likely suggesting a different underlying neurobiological mechanism. Here I examined several aspects of gyrification in an accelerated longitudinal dataset of 280 healthy adults aged 45–92 with an interval between first and last MRI sessions of up to 10 years (total of 815 MRI sessions). Results suggest that age changes in sulcal morphology underlie these changes in gyrification.

• Journal Article Type: Article
• Acceptance Date: Oct 31, 2020
• Online Publication Date: Nov 23, 2020
• Publication Date: 2021-03
• Deposit Date: Nov 1, 2020
• Publicly Available Date: Nov 24, 2021
• Journal: European Journal of Neuroscience
• Print ISSN: 0953-816X
• Electronic ISSN: 1460-9568
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 53
• Issue: 5
• Pages: 1661-1671
• DOI: https://doi.org/10.1111/ejn.15039
• Public URL: https://nottingham-repository.worktribe.com/output/4106485
• Publisher URL: https://onlinelibrary.wiley.com/doi/10.1111/ejn.15039
• Additional Information: This is the peer reviewed version of the following article: Madan, CR. Age?related decrements in cortical gyrification: Evidence from an accelerated longitudinal dataset. Eur J Neurosci. 2020, which has been published in final form at https://doi.org/10.1111/ejn.15039. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.