J. E. M. Blackwell
High-intensity interval training produces a significant improvement in fitness in less than 31 days before surgery for urological cancer: a randomised control trial
Blackwell, J. E. M.; Doleman, B.; Boereboom, C. L; Morton, A.; Williams, S.; Atherton, P.; Smith, K.; Williams, J. P.; Phillips, B. E.; Lund, J. N.
Authors
B. Doleman
C. L Boereboom
A. Morton
S. Williams
PHILIP ATHERTON philip.atherton@nottingham.ac.uk
Professor of Clinical, metabolic & Molecular Physiology
KENNETH SMITH KEN.SMITH@NOTTINGHAM.AC.UK
Professor of Metabolic Mass Spectrometry
J. P. Williams
BETH PHILLIPS beth.phillips@nottingham.ac.uk
Professor of Translational Physiology
JONATHAN LUND JON.LUND@NOTTINGHAM.AC.UK
Clinical Associate Professor
Abstract
Objectives
To assess the efficacy of high-intensity interval training (HIIT) for improving cardiorespiratory fitness (CRF) in patients awaiting resection for urological malignancy within four weeks.
Subjects/patients and methods
A randomised control trial of consecutive patients aged (>65 years) scheduled for major urological surgery in a large secondary referral centre in a UK hospital. The primary outcome is change in anaerobic threshold (VO2AT) following HIIT vs. standard care.
Results
Forty patients were recruited (mean age 72 years, male (39): female (1)) with 34 completing the protocol. Intention to treat analysis showed significant improvements in anaerobic threshold (VO2AT; mean difference (MD) 2.26 ml/kg/min (95% CI 1.25–3.26)) following HIIT. Blood pressure (BP) also significantly reduced in following: HIIT (SBP: −8.2 mmHg (95% CI −16.09 to −0.29) and DBP: −6.47 mmHg (95% CI −12.56 to −0.38)). No reportable adverse safety events occurred during HIIT and all participants achieved >85% predicted maximum heart rate during sessions, with protocol adherence of 84%.
Conclusions
HIIT can improve CRF and cardiovascular health, representing clinically meaningful and achievable pre-operative improvements. Larger randomised trials are required to investigate the efficacy of prehabilitation HIIT upon different cancer types, post-operative complications, socio-economic impact and long-term survival.
Citation
Blackwell, J. E. M., Doleman, B., Boereboom, C. L., Morton, A., Williams, S., Atherton, P., …Lund, J. N. (2020). High-intensity interval training produces a significant improvement in fitness in less than 31 days before surgery for urological cancer: a randomised control trial. Prostate Cancer and Prostatic Diseases, 23, 696–704. https://doi.org/10.1038/s41391-020-0219-1
Journal Article Type | Article |
---|---|
Acceptance Date | Feb 19, 2020 |
Online Publication Date | Mar 10, 2020 |
Publication Date | 2020-12 |
Deposit Date | Feb 17, 2020 |
Publicly Available Date | Mar 12, 2020 |
Journal | Prostate Cancer and Prostatic Diseases |
Print ISSN | 1365-7852 |
Electronic ISSN | 1476-5608 |
Publisher | Nature Publishing Group |
Peer Reviewed | Peer Reviewed |
Volume | 23 |
Pages | 696–704 |
DOI | https://doi.org/10.1038/s41391-020-0219-1 |
Keywords | Urology; Cancer Research; Oncology |
Public URL | https://nottingham-repository.worktribe.com/output/3977881 |
Publisher URL | https://www.nature.com/articles/s41391-020-0219-1 |
Additional Information | Received: 17 December 2019; Revised: 11 February 2020; Accepted: 19 February 2020; First Online: 10 March 2020; : ; : The authors declare that they have no conflict of interest. |
Files
s41391-020-0219-1
(1.1 Mb)
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Publisher Licence URL
https://creativecommons.org/licenses/by/4.0/
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