Henrik M�ller
Short-term breast cancer survival in relation to ethnicity, stage, grade and receptor status: National cohort study in England
M�ller, Henrik; Henson, Katherine; L�chtenborg, Margreet; Broggio, John; Charman, Jackie; Coupland, Victoria H.; Davies, Elizabeth; Jack, Ruth H.; Sullivan, Richard; Vedsted, Peter; Horgan, Kieran; Pearce, Neil; Purushotham, Arnie
Authors
Katherine Henson
Margreet L�chtenborg
John Broggio
Jackie Charman
Victoria H. Coupland
Elizabeth Davies
RUTH JACK Ruth.Jack@nottingham.ac.uk
Senior Research Fellow
Richard Sullivan
Peter Vedsted
Kieran Horgan
Neil Pearce
Arnie Purushotham
Abstract
Background:In the re-organisation of cancer registration in England in 2012, a high priority was given to the recording of cancer stage and other prognostic clinical data items.Methods:We extracted 86 852 breast cancer records for women resident in England and diagnosed during 2012-2013. Information on age, ethnicity, socio-economic status, comorbidity, tumour stage, grade, morphology and oestrogen, progesterone and HER2 receptor status was included. The two-year cumulative risk of death from any cause was estimated with the Kaplan-Meier method, and univariate and multivariate Cox proportional hazards regressions were used to estimate hazard ratios (HR) and their 95% confidence intervals (95% CI). The follow-up ended on 31 December 2014.Results:The completeness of registration for prognostic variables was generally high (around 80% or higher), but it was low for progesterone receptor status (41%). Women with negative receptor status for each of the oestrogen, progesterone and HER2 receptors (triple-negative cancers) had an adjusted HR for death of 2.00 (95%CI 1.84-2.17). Black women had an age-adjusted HR of 1.77 (1.48-2.13) compared with White women.Conclusions:The excess mortality of Black women with breast cancer has contributions from socio-economic factors, stage distribution and tumour biology. The study illustrates the richness of detail in the national cancer registration data. This allows for analysis of cancer outcomes at a high level of resolution, and may form the basis for risk stratification.
Journal Article Type | Article |
---|---|
Acceptance Date | Sep 25, 2016 |
Online Publication Date | Oct 25, 2016 |
Publication Date | Nov 22, 2016 |
Deposit Date | Sep 24, 2020 |
Publicly Available Date | Feb 1, 2021 |
Journal | British Journal of Cancer |
Print ISSN | 0007-0920 |
Electronic ISSN | 1532-1827 |
Publisher | Cancer Research UK |
Peer Reviewed | Peer Reviewed |
Volume | 115 |
Issue | 11 |
Pages | 1408-1415 |
DOI | https://doi.org/10.1038/bjc.2016.335 |
Keywords | breast cancer survival; ethnicity; stage; grade; receptors |
Public URL | https://nottingham-repository.worktribe.com/output/3223641 |
Publisher URL | https://www.nature.com/articles/bjc2016335 |
Files
Moller Br J Cancer 2016
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Publisher Licence URL
https://creativecommons.org/licenses/by-nc-sa/4.0/
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