Crohn disease: A current perspective on genetics, autophagy and immunity

Stappenbeck, Thaddeus S.; Rioux, John D.; Mizoguchi, Atsushi; Saitoh, Tatsuya; Huett, Alan; Darfeuille-Michaud, Arlette; Wileman, Tom; Mizushima, Noboru; Carding, Simon; Akira, Shizuo; Parkes, Miles; Xavier, Ramnik J.

Abstract

Crohn disease (CD) is a chronic and debilitating inflammatory condition of the gastrointestinal tract.1 Prevalence in western populations is 100-150/100,000 and somewhat higher in Ashkenazi Jews. Peak incidence is in early adult life, although any age can be affected and a majority of affected individuals progress to relapsing and chronic disease. Medical treatments rely significantly on empirical corticosteroid therapy and immunosuppression, and intestinal resectional surgery is frequently required. Thus, 80% of patients with CD come to surgery for refractory disease or complications. It is hoped that an improved understanding of pathogenic mechanisms, for example by studying the genetic basis of CD and other forms of inflammatory bowel diseases (IBD), will lead to improved therapies and possibly preventative strategies in individuals identified as being at risk. © 2011 Landes Bioscience.

Citation

Stappenbeck, T. S., Rioux, J. D., Mizoguchi, A., Saitoh, T., Huett, A., Darfeuille-Michaud, A., …Xavier, R. J. (2011). Crohn disease: A current perspective on genetics, autophagy and immunity. Autophagy, 7(4), 355-374. https://doi.org/10.4161/auto.7.4.13074

• Journal Article Type: Review
• Acceptance Date: Apr 17, 2010
• Online Publication Date: Apr 1, 2011
• Publication Date: Apr 1, 2011
• Deposit Date: Aug 15, 2022
• Journal: Autophagy
• Print ISSN: 1554-8627
• Electronic ISSN: 1554-8635
• Publisher: Taylor and Francis
• Peer Reviewed: Peer Reviewed
• Volume: 7
• Issue: 4
• Pages: 355-374
• DOI: https://doi.org/10.4161/auto.7.4.13074
• Keywords: dendritic cells, gut microbiota, inflammatory bowel diseases, gastrointestinal, Atg16L1, Paneth cell, ulcerative colitis, IRGM, genome-wide association
• Public URL: https://nottingham-repository.worktribe.com/output/3181783
• Publisher URL: https://www.tandfonline.com/doi/abs/10.4161/auto.7.4.13074