Engineering periodontal tissue interfaces using multiphasic scaffolds and membranes for guided bone and tissue regeneration

Ozkendir, Ozgu; Karaca, Ilayda; Cullu, Selin; Erdoğan, Oğul Can; Yaşar, Hüsniye Nur; Dikici, Serkan; Owen, Robert; Aldemir Dikici, Betül

Abstract

Periodontal diseases are one of the greatest healthcare burdens worldwide. The periodontal tissue compartment is an anatomical tissue interface formed from the periodontal ligament, gingiva, cementum, and bone. This multifaceted composition makes tissue engineering strategies challenging to develop due to the interface of hard and soft tissues requiring multiphase scaffolds to recreate the native tissue architecture. Multilayer constructs can better mimic tissue interfaces due to the individually tuneable layers. They have different characteristics in each layer, with modulation of mechanical properties, material type, porosity, pore size, morphology, degradation properties, and drug-releasing profile all possible. The greatest challenge of multilayer constructs is to mechanically integrate consecutive layers to avoid delamination, especially when using multiple manufacturing processes. Here, we review the development of multilayer scaffolds that aim to recapitulate native periodontal tissue interfaces in terms of physical, chemical, and biological characteristics. Important properties of multiphasic biodegradable scaffolds are highlighted and summarised, with design requirements, biomaterials, and fabrication methods, as well as post-treatment and drug/growth factor incorporation discussed.

Citation

Ozkendir, O., Karaca, I., Cullu, S., Erdoğan, O. C., Yaşar, H. N., Dikici, S., Owen, R., & Aldemir Dikici, B. (2024). Engineering periodontal tissue interfaces using multiphasic scaffolds and membranes for guided bone and tissue regeneration. Biomaterials Advances, 157, Article 213732. https://doi.org/10.1016/j.bioadv.2023.213732

• Journal Article Type: Review
• Acceptance Date: Dec 11, 2023
• Online Publication Date: Dec 16, 2023
• Publication Date: 2024-02
• Deposit Date: Feb 1, 2024
• Publicly Available Date: Dec 17, 2024
• Journal: Biomaterials Advances
• Electronic ISSN: 2772-9508
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 157
• Article Number: 213732
• DOI: https://doi.org/10.1016/j.bioadv.2023.213732
• Keywords: Biomaterials, GBR, GTR, Tissue engineering, Guided bone regeneration, Periodontitis
• Public URL: https://nottingham-repository.worktribe.com/output/29539303
• Publisher URL: https://www.sciencedirect.com/science/article/pii/S2772950823004557