Perceptions, definitions, and therapeutic interventions for occasional constipation: a ROME working group consensus document

Brenner, Darren M.; Corsetti, Maura; Drossman, Douglas; Tack, Jan; Wald, Arnold

Abstract

Background & Aims: Functional constipation is the most common of the disorders of gut-brain interaction, affecting approximately 12% of the world population. Although classically considered a chronic condition, many individuals experience shorter yet repetitive bouts of constipation representing a different clinical entity. There has been increased interest in this latter disorder, which has recently been classified as occasional constipation. This Rome Foundation working group document reflects the consensus of an international team of specialists who summarized currently available research to provide a working definition of and treatment algorithm for occasional constipation. The recommendations herein are based on current evidence, accounting for gaps in the literature as well as international variance in definitions and health seeking behaviors for constipation. Methods: The committee members reviewed the scientific literature, focusing specifically on occasional constipation, with the understanding that as a new entity, a paucity of data would be available. We used Rome IV research and clinical definitions to establish the framework for our definition of occasional constipation. Where possible, treatment recommendations were determined on the basis of the earliest extractable data from functional constipation studies, focusing on positive results within the first 2 weeks of treatment. We used the Delphi method to create consensus with 100% agreement between the authors. Results: An evidence-based review of the literature resulted in the definition of occasional constipation as follows: “individuals who experience the presence of at least 1 functional constipation symptom, in the absence of alarm signs or symptoms, occurring at irregular and infrequent intervals, which is bothersome enough to induce a patient to seek medical management.” Medical management whether seeking medical care or self-treatment was left to the individual's discretion, and we did not include time anchors because these thresholds require further investigation. Polyethylene glycol and stimulant laxatives are recommended as first-line interventions, whereas magnesium-containing compounds are suggested in individuals failing to respond to these therapies. There are insufficient data to make recommendations for using fiber or stool softeners. Prescription laxatives should be reserved for individuals with chronic constipation. Conclusions: Occasional constipation is a unique clinical entity characterized by infrequent but recurrent symptoms. Data are limited because consensus definitions have been lacking. Establishing a standardized definition and therapeutic recommendations provides a framework for future studies focusing on epidemiologic and symptoms-based outcomes. Further studies are needed to confirm and refine these recommendations.

Citation

Brenner, D. M., Corsetti, M., Drossman, D., Tack, J., & Wald, A. (2024). Perceptions, definitions, and therapeutic interventions for occasional constipation: a ROME working group consensus document. Clinical Gastroenterology and Hepatology, 22(2), 397-412. https://doi.org/10.1016/j.cgh.2023.08.044

• Journal Article Type: Article
• Acceptance Date: Aug 14, 2023
• Online Publication Date: Oct 3, 2023
• Publication Date: 2024-02
• Deposit Date: Oct 23, 2023
• Publicly Available Date: Dec 21, 2023
• Journal: Clinical Gastroenterology and Hepatology
• Print ISSN: 1542-3565
• Electronic ISSN: 1542-7714
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 22
• Issue: 2
• Pages: 397-412
• DOI: https://doi.org/10.1016/j.cgh.2023.08.044
• Keywords: Laxatives, Occasional Constipation, Functional Constipation, Fiber, Constipation
• Public URL: https://nottingham-repository.worktribe.com/output/26519545
• Publisher URL: https://www.cghjournal.org/article/S1542-3565(23)00759-0/fulltext