Venetoclax ramp-up strategies for chronic lymphocytic leukaemia in the United Kingdom: a real world multicentre retrospective study

Figueroa‐Mora, Rocio; Rampotas, Alexandros; Halperin, Daniel; Worth, Tina; Vidler, Jennifer; Melotti, Dario; Ferguson, Paul; Elmusharaf, Nagah; Preston, Gavin; Furtado, Michelle; Dungarwalla, Moez; Gohill, Satyen; Patten, Piers; Kennedy, Ben; Eyre, Toby A.; Schuh, Anna; Fox, Christopher P.; Munir, Tahla; Martinez‐Calle, Nicolas

Abstract

This retrospective, observational study evaluated patterns of inpatient versus outpatient tumour lysis syndrome (TLS) monitoring during venetoclax ramp-up in 170 patients with chronic lymphocytic leukaemia. The primary outcome was clinical/biochemical TLS. Two clinical and four biochemical TLS occurred (4.1%). Five of the six events occurred in high-risk patients, four occurred at 20 mg dose and three at the 6-h time-point. Inpatient versus outpatient TLS rates within the high-risk subgroup were 15% and 8%. Risk category was the only predictor of TLS events in multivariate analysis. Outpatient escalation did not associate with clinically meaningful TLS events, suggesting outpatient escalation has manageable associated TLS risks, including in high-risk cohorts. These observations require confirmation in larger studies.

Citation

Figueroa‐Mora, R., Rampotas, A., Halperin, D., Worth, T., Vidler, J., Melotti, D., …Martinez‐Calle, N. (2023). Venetoclax ramp-up strategies for chronic lymphocytic leukaemia in the United Kingdom: a real world multicentre retrospective study. British Journal of Haematology, 202(1), 48-53. https://doi.org/10.1111/bjh.18738

• Journal Article Type: Article
• Acceptance Date: Feb 24, 2023
• Online Publication Date: Mar 23, 2023
• Publication Date: 2023-07
• Deposit Date: Sep 20, 2023
• Publicly Available Date: Sep 20, 2023
• Journal: British Journal of Haematology
• Print ISSN: 0007-1048
• Electronic ISSN: 1365-2141
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 202
• Issue: 1
• Pages: 48-53
• DOI: https://doi.org/10.1111/bjh.18738
• Keywords: Chronic lymphocytic leukaemia; dose ramp-up; tumour lysis syndrome; Venetoclax
• Public URL: https://nottingham-repository.worktribe.com/output/25364459
• Publisher URL: https://onlinelibrary.wiley.com/doi/10.1111/bjh.18738
• Additional Information: Received: 2022-12-21; Accepted: 2023-02-24; Published: 2023-03-23