Poly(triazolyl methacrylate) glycopolymers as potential targeted unimolecular nanocarriers

Madeira Do O, J.; Foralosso, R.; Yilmaz, G.; Mastrotto, F.; King, P. J. S.; Xerri, R. M.; He, Y.; Van Der Walle, C. F.; Fernandez-Trillo, F.; Laughton, C.A.; Styliari, I.; Stolnik, S.; Mantovani, G.

Abstract

Synthetic glycopolymers are increasingly investigated as multivalent ligands for a range of biological and biomedical applications. This study indicates that glycopolymers with fine-tuned balance between hydrophilic sugar pendant units and relatively hydrophobic polymer backbones can act as single-chain targeted nanocarriers for low molecular weight hydrophobic molecules. Non-covalent complexes formed from poly(triazolyl methacrylate) glycopolymers and low molecular weight hydrophobic guest molecules were characterised through a range of analytical techniques-DLS, SLS, TDA, fluorescence spectroscopy, surface tension analysis-and molecular dynamics (MD) modelling simulations provided further information on the macromolecular characteristics of these single chain complexes. Finally, we show that these nanocarriers can be utilised to deliver hydrophobic guest molecule, Nile Red, to both soluble and surface-immobilised concanavalin A (Con A) and peanut agglutinin (PNA) model lectins with high specificity, showing the potential of non-covalent complexation with specific glycopolymers in targeted guest-molecule delivery

Citation

Madeira Do O, J., Foralosso, R., Yilmaz, G., Mastrotto, F., King, P. J. S., Xerri, R. M., …Mantovani, G. (2019). Poly(triazolyl methacrylate) glycopolymers as potential targeted unimolecular nanocarriers. Nanoscale, 11(44), 21155-21166. https://doi.org/10.1039/C9NR05836B

• Journal Article Type: Article
• Acceptance Date: Aug 28, 2019
• Online Publication Date: Oct 29, 2019
• Publication Date: Oct 29, 2019
• Deposit Date: Aug 30, 2019
• Publicly Available Date: Nov 1, 2019
• Journal: Nanoscale
• Print ISSN: 2040-3364
• Electronic ISSN: 2040-3372
• Publisher: Royal Society of Chemistry
• Peer Reviewed: Peer Reviewed
• Volume: 11
• Issue: 44
• Pages: 21155-21166
• DOI: https://doi.org/10.1039/C9NR05836B
• Keywords: General Materials Science
• Public URL: https://nottingham-repository.worktribe.com/output/2521723
• Publisher URL: https://pubs.rsc.org/en/content/articlelanding/2019/nr/c9nr05836b#!divAbstract
• Additional Information: : This document is Similarity Check deposited; : Supplementary Information; : G. Yilmaz (ORCID); : F. Mastrotto (ORCID); : Y. He (ORCID); : C. F. van der Walle (ORCID); : F. Fernandez-Trillo (ORCID); : F. Fernandez-Trillo (ResearcherID); : C. A. Laughton (ORCID); : C. A. Laughton (ResearcherID); : I. Styliari (ORCID); : S. Stolnik (ORCID); : G. Mantovani (ORCID); : G. Mantovani (ResearcherID); : Single-blind; : Received 9 July 2019; Accepted 28 August 2019; Accepted Manuscript published 29 October 2019; Advance Article published 30 October 2019