Rhodium-catalyzed arylative cyclization of alkynyl malonates by 1,4-rhodium(I) migration

O'Brien, Luke; Karad, Somnath Narayan; Lewis, William; Lam, Hon Wai

Abstract

The synthesis of functionalized 1-tetralones by the rhodium(I)-catalyzed reaction of alkynyl malonates with arylboronic acids is described. These arylative cyclizations proceed via an alkenyl-to-aryl 1,4-Rh(I) migration as a key step. Preliminary results of an enantioselective variant of these reactions are also presented.

Citation

O'Brien, L., Karad, S. N., Lewis, W., & Lam, H. W. (2019). Rhodium-catalyzed arylative cyclization of alkynyl malonates by 1,4-rhodium(I) migration. Chemical Communications, 55(76), 11366-11369. https://doi.org/10.1039/c9cc05205d

• Journal Article Type: Article
• Acceptance Date: Aug 19, 2019
• Online Publication Date: Aug 26, 2019
• Publication Date: Sep 28, 2019
• Deposit Date: Aug 26, 2019
• Publicly Available Date: Aug 27, 2020
• Journal: Chemical Communications
• Print ISSN: 1359-7345
• Electronic ISSN: 1364-548X
• Publisher: Royal Society of Chemistry
• Peer Reviewed: Peer Reviewed
• Volume: 55
• Issue: 76
• Pages: 11366-11369
• DOI: https://doi.org/10.1039/c9cc05205d
• Keywords: Materials chemistry; Electronic, optical and magnetic materials; General chemistry; Surfaces, Coatings and films; Metals and alloys; Ceramics and composites; Catalysis
• Public URL: https://nottingham-repository.worktribe.com/output/2503472
• Publisher URL: https://pubs.rsc.org/en/Content/ArticleLanding/2019/CC/C9CC05205D#!divAbstract
• Contract Date: Aug 26, 2019