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Rhodium-catalyzed arylative cyclization of alkynyl malonates by 1,4-rhodium(I) migration

O'Brien, Luke; Karad, Somnath Narayan; Lewis, William; Lam, Hon Wai

Authors

Luke O'Brien

Somnath Narayan Karad

William Lewis

Hon Wai Lam



Abstract

The synthesis of functionalized 1-tetralones by the rhodium(I)-catalyzed reaction of alkynyl malonates with arylboronic acids is described. These arylative cyclizations proceed via an alkenyl-to-aryl 1,4-Rh(I) migration as a key step. Preliminary results of an enantioselective variant of these reactions are also presented.

Journal Article Type Article
Publication Date Sep 28, 2019
Journal Chemical Communications
Print ISSN 1359-7345
Electronic ISSN 1364-548X
Publisher Royal Society of Chemistry
Peer Reviewed Peer Reviewed
Volume 55
Issue 76
Pages 11366-11369
APA6 Citation O'Brien, L., Karad, S. N., Lewis, W., & Lam, H. W. (2019). Rhodium-catalyzed arylative cyclization of alkynyl malonates by 1,4-rhodium(I) migration. Chemical Communications, 55(76), 11366-11369. https://doi.org/10.1039/c9cc05205d
DOI https://doi.org/10.1039/c9cc05205d
Keywords Materials chemistry; Electronic, optical and magnetic materials; General chemistry; Surfaces, Coatings and films; Metals and alloys; Ceramics and composites; Catalysis
Publisher URL https://pubs.rsc.org/en/Content/ArticleLanding/2019/CC/C9CC05205D#!divAbstract
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