Gut microbiome-based dietary intervention in Parkinson disease subject: A case report

Sulthana, Ayesha; Paneyala, Shasthara; Narayan, Meghana Kowlagi; Ahmed Hediyal, Tousif; Sharma, Sonali; Senthilkumar, Arunsaikiran; Dave, Paul; Mahalakshmi, Arehally M; Chidambaram, Saravana Babu; Monaghan, Tanya M; Sulakhe, Dinanath

Abstract

A 54-year-old woman was seeking medical treatment for Parkinson disease (PD) in the neurology outpatient department in JSS Hospital, Mysore, India. She was challenged in terms of reduced mobility and had sought several treatment options to control her PD symptoms without successful outcome. After examination and confirmation of diagnosis, the decision was taken to design a precision nutritional intervention using a gut microbiome-based diet combined with medical treatment. After 2 months of a superfood dietary intervention, the patient showed signs of clinical improvement as evidenced by improved mobility and a change in the Hoehn and Yahr clinical severity scale from stages 3 to 2. In conclusion, it is possible to modulate the gut microbiome to reverse the established gut dysbiosis associated with the neurodegenerative process in PD, which can lead to clinical benefit by reducing functional disability.

Citation

Sulthana, A., Paneyala, S., Narayan, M. K., Ahmed Hediyal, T., Sharma, S., Senthilkumar, A., …Sulakhe, D. (2023). Gut microbiome-based dietary intervention in Parkinson disease subject: A case report. International Journal of Nutrition, Pharmacology, Neurological Diseases, 13(3), 158-165. https://doi.org/10.4103/ijnpnd.ijnpnd_8_23

• Journal Article Type: Article
• Acceptance Date: Mar 20, 2023
• Online Publication Date: Jul 27, 2023
• Publication Date: 2023-07
• Deposit Date: Jul 31, 2023
• Publicly Available Date: Aug 16, 2023
• Journal: International Journal of Nutrition, Pharmacology, Neurological Diseases
• Print ISSN: 2231-0738
• Publisher: Medknow Publications
• Peer Reviewed: Peer Reviewed
• Volume: 13
• Issue: 3
• Pages: 158-165
• DOI: https://doi.org/10.4103/ijnpnd.ijnpnd_8_23
• Keywords: Gut microbiome; Parkinson disease; Gut dysbiosis; Nutrition; Precision diet
• Public URL: https://nottingham-repository.worktribe.com/output/23632594
• Publisher URL: https://journals.lww.com/ijnp/Fulltext/2023/13030/Gut_microbiome_based_dietary_intervention_in.5.aspx