Addressing unmet needs in understanding asthma mechanisms

Edwards, Michael R.; Saglani, Sejal; Schwarze, Jurgen; Skevaki, Chrysanthi; Smith, Jaclyn A.; Ainsworth, Ben; Almond, Mark; Andreakos, Evangelos; Belvisi, Maria G.; Chung, Kian Fan; Cookson, William; Cullinan, Paul; Hawrylowicz, Catherine; Lommatzsch, Marek; Jackson, David; Lutter, Rene; Marsland, Benjamin; Moffatt, Miriam; Thomas, Mike; Virchow, J. Christian; Xanthou, Georgina; Edwards, Jessica; Walker, Samantha; Johnston, Sebastian L.; Adcock, Ian; Akdis, Cezmi; Bel, Elisabeth; Bousquet, Jean; Ten Brinke, Anneke; Brusselle, Guy; Dáhlen, Sven Erik; Djukanovic, Ratko; Gaga, Mina; Garcia-Marcos, Luis; Hiemstra, Pieter; Heffler, Enrico; Holgate, Stephen; Kupczyk, Maciek; Lloyd, Clare; Lucas, Jane; Magnan, Antoine; Martin, Thomas; Myles, David; Page, Clive; Palkonen, Susanna; Papadopoulos, Nikos; Papi, Alberto; Powell, Pippa; Riley, John; Sayers, Ian; Spanevello, Antonio; Sterk, Peter; Xepapadaki, Paraskevi; Wheelock, Craig

Abstract

Asthma is a heterogeneous, complex disease with clinical phenotypes that incorporate persistent symptoms and acute exacerbations. It affects many millions of Europeans throughout their education and working lives and puts a heavy cost on European productivity. There is a wide spectrum of disease severity and control. Therapeutic advances have been slow despite greater understanding of basic mechanisms and the lack of satisfactory preventative and disease modifying management for asthma constitutes a significant unmet clinical need. Preventing, treating and ultimately curing asthma requires co-ordinated research and innovation across Europe. The European Asthma Research and Innovation Partnership (EARIP) is an FP7-funded programme which has taken a co-ordinated and integrated approach to analysing the future of asthma research and development. This report aims to identify the mechanistic areas in which investment is required to bring about significant improvements in asthma outcomes.

Citation

Edwards, M. R., Saglani, S., Schwarze, J., Skevaki, C., Smith, J. A., Ainsworth, B., …Wheelock, C. (2017). Addressing unmet needs in understanding asthma mechanisms. European Respiratory Journal, 49(5), Article 1602448. https://doi.org/10.1183/13993003.02448-2016

• Journal Article Type: Review
• Acceptance Date: Mar 13, 2017
• Online Publication Date: May 13, 2017
• Publication Date: 2017
• Deposit Date: Mar 14, 2024
• Journal: European Respiratory Journal
• Print ISSN: 0903-1936
• Publisher: European Respiratory Society
• Peer Reviewed: Peer Reviewed
• Volume: 49
• Issue: 5
• Article Number: 1602448
• DOI: https://doi.org/10.1183/13993003.02448-2016
• Public URL: https://nottingham-repository.worktribe.com/output/23529828