Switching from linear to macrocyclic gadolinium‐based contrast agents halts the relative T 1 ‐Weighted signal increase in deep gray matter of children with brain tumors: A retrospective study

Rowe, Selene K.; Rodriguez, Daniel; Cohen, Ellie; Grundy, Richard; Morgan, Paul S.; Jaspan, Tim; Dineen, Robert A.

Abstract

Background

Studies have shown signal intensity (SI) changes in the brains of children exposed to repeated doses of a gadolinium‐based contrast agent (GBCA).
Hypothesis

The trajectory of changes in relative dentate nucleus (DN) and globus pallidus (GP) SI in children receiving multiple doses of GBCA will alter when switched from linear to macrocyclic agents.
Study Type

Retrospective longitudinal.
Population

Thirty‐five children, age range 0.5–17.0 years, undergoing brain tumor follow‐up between 2006 and 2017.
Field Strength/Sequence

Unenhanced T1WI, serial scans at both 1.5T and 3T.
Assessment

Regions of interest were drawn on DN, GP, and SIs normalized to middle cerebellar peduncle (DN/MCP) and cerebral white matter (GP/CWM), respectively. A change in SI ratios as a function of dose (slope gradient) calculated according to the type of contrast agent received: linear only, macrocyclic only, or switchover from linear to macrocyclic. For the latter, gradients were compared before and after switchover. The effect of anticancer treatment on slope gradient was tested.
Statistical Tests

One‐sample t‐test or Mann–Whitney U‐test for slope gradients differing from zero. Independent samples t‐tests to compare slope gradient groups. Paired sample t‐tests to compare slope gradients before and after switchover.
Results

A significant (P < 0.05) increase in SI ratio was observed following multiple doses of linear but not macrocyclic agents: mean percentage increase per dose in SI was 0.063% vs. –0.034% for DN/MCP, and 0.078% vs. 0.004% for GP/CWM ratios. A significant (P < 0.05) change of SI trajectory in the DN/MCP ratio was demonstrated when switching from a linear to macrocyclic agent. There was no difference in SI trajectory between patients who had anticancer therapies and those who did not, DN/MCP P = 0.740; GP/BWM P = 0.694.
Data Conclusion

Switching from linear to macrocyclic gadolinium‐based contrast agents seems to halt the relative T1 signal increase in deep gray matter in children. Anticancer treatments appeared to have no impact on the trajectory of T1 SI.

Citation

Rowe, S. K., Rodriguez, D., Cohen, E., Grundy, R., Morgan, P. S., Jaspan, T., & Dineen, R. A. (2019). Switching from linear to macrocyclic gadolinium‐based contrast agents halts the relative T 1 ‐Weighted signal increase in deep gray matter of children with brain tumors: A retrospective study. Journal of Magnetic Resonance Imaging, https://doi.org/10.1002/jmri.26831

• Journal Article Type: Article
• Acceptance Date: May 24, 2019
• Online Publication Date: Jun 4, 2019
• Publication Date: Jun 4, 2019
• Deposit Date: Jun 7, 2019
• Publicly Available Date: Jun 5, 2020
• Journal: Journal of Magnetic Resonance Imaging
• Print ISSN: 1053-1807
• Electronic ISSN: 1522-2586
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• DOI: https://doi.org/10.1002/jmri.26831
• Keywords: Radiology Nuclear Medicine and imaging
• Public URL: https://nottingham-repository.worktribe.com/output/2158897
• Publisher URL: https://onlinelibrary.wiley.com/doi/full/10.1002/jmri.26831
• Additional Information: This is the peer reviewed version of the following article: Rowe, S. K., Rodriguez, D. , Cohen, E. , Grundy, R. , Morgan, P. S., Jaspan, T. and Dineen, R. A. (2019), Switching from linear to macrocyclic gadolinium‐based contrast agents halts the relative T1‐Weighted signal increase in deep gray matter of children with brain tumors: A retrospective study. J Magn Reson Imaging. , which has been published in final form at doi:10.1002/jmri.26831. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
• Contract Date: Jun 7, 2019