Venous thromboembolism following colectomy for diverticular disease: an English population-based cohort study

Yapa, Anjali K D S; Humes, David J; Crooks, Colin J; Lewis-Lloyd, Christopher A

Abstract

Aim
This study reports venous thromboembolism (VTE) rates following colectomy for diverticular disease to explore the magnitude of postoperative VTE risk in this population and identify high risk subgroups of interest.

Method
English national cohort study of colectomy patients between 2000 and 2019 using linked primary (Clinical Practice Research Datalink) and secondary (Hospital Episode Statistics) care data. Stratified by admission type, absolute incidence rates (IR) per 1000 person-years and adjusted incidence rate ratios (aIRR) were calculated for 30- and 90-day post-colectomy VTE.

Results
Of 24,394 patients who underwent colectomy for diverticular disease, over half (57.39%) were emergency procedures with the highest VTE rate seen in patients ≥70-years-old (IR 142.27 per 1000 person-years, 95%CI 118.32–171.08) at 30 days post colectomy. Emergency resections (IR 135.18 per 1000 person-years, 95%CI 115.72–157.91) had double the risk (aIRR 2.07, 95%CI 1.47–2.90) of developing a VTE at 30 days following colectomy compared to elective resections (IR 51.14 per 1000 person-years, 95%CI 38.30–68.27). Minimally invasive surgery (MIS) was shown to be associated with a 64% reduction in VTE risk (aIRR 0.36 95%CI 0.20–0.65) compared to open colectomies at 30 days post-op. At 90 days following emergency resections, VTE risks remained raised compared to elective colectomies.

Conclusion
Following emergency colectomy for diverticular disease, the VTE risk is approximately double compared to elective resections at 30 days while MIS was found to be associated with a reduced risk of VTE. This suggests advancements in postoperative VTE prevention in diverticular disease patients should focus on those undergoing emergency colectomies.

• Journal Article Type: Article
• Acceptance Date: Apr 29, 2023
• Online Publication Date: May 22, 2023
• Publication Date: May 22, 2023
• Deposit Date: Jul 21, 2023
• Publicly Available Date: Jul 24, 2023
• Journal: Langenbeck's Archives of Surgery
• Print ISSN: 1435-2443
• Electronic ISSN: 1435-2451
• Peer Reviewed: Peer Reviewed
• Volume: 408
• Article Number: 203
• DOI: https://doi.org/10.1007/s00423-023-02920-6
• Keywords: Colectomy, Venous thromboembolism, Emergency, Diverticular disease
• Public URL: https://nottingham-repository.worktribe.com/output/21363393
• Publisher URL: https://link.springer.com/article/10.1007/s00423-023-02920-6