Progress in low-field benchtop NMR spectroscopy in chemical and biochemical analysis

Grootveld, Martin; Percival, Benita; Gibson, Miles; Osman, Yasan; Edgar, Mark; Molinari, Marco; Mather, Melissa L.; Casanova, Federico; Wilson, Philippe B.

Abstract

© 2019 Elsevier B.V. The employment of spectroscopically-resolved NMR techniques as analytical probes have previously been both prohibitively expensive and logistically challenging in view of the large sizes of high-field facilities. However, with recent advances in the miniaturisation of magnetic resonance technology, low-field, cryogen-free “benchtop” NMR instruments are seeing wider use. Indeed, these miniaturised spectrometers are utilised in areas ranging from food and agricultural analyses, through to human biofluid assays and disease monitoring. Therefore, it is both intrinsically timely and important to highlight current applications of this analytical strategy, and also provide an outlook for the future, where this approach may be applied to a wider range of analytical problems, both qualitatively and quantitatively.

Citation

Grootveld, M., Percival, B., Gibson, M., Osman, Y., Edgar, M., Molinari, M., …Wilson, P. B. (2019). Progress in low-field benchtop NMR spectroscopy in chemical and biochemical analysis. Analytica Chimica Acta, 1067, 11-30. https://doi.org/10.1016/j.aca.2019.02.026

• Journal Article Type: Article
• Acceptance Date: Feb 19, 2019
• Online Publication Date: Feb 23, 2019
• Publication Date: Aug 27, 2019
• Deposit Date: May 28, 2019
• Journal: Analytica Chimica Acta
• Print ISSN: 0003-2670
• Electronic ISSN: 1873-4324
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 1067
• Pages: 11-30
• DOI: https://doi.org/10.1016/j.aca.2019.02.026
• Keywords: Analytical Chemistry; Spectroscopy; Biochemistry; Environmental Chemistry
• Public URL: https://nottingham-repository.worktribe.com/output/2102367
• Publisher URL: https://www.sciencedirect.com/science/article/pii/S0003267019302028?via%3Dihub