JASPER ROBINSON JASPER.ROBINSON@NOTTINGHAM.AC.UK
Associate Professor
Familiarity-based stimulus generalization of conditioned suppression in rats is dependent on the perirhinal cortex
Robinson, Jasper; Whitt, Emma J.; Horsley, Rachel R.; Jones, Peter M.
Authors
EMMA WHITT EMMA.WHITT@NOTTINGHAM.AC.UK
Associate Professor
Rachel R. Horsley
Peter M. Jones
Abstract
We report that bilateral, excitoxic lesions of the perirhinal cortex attenuate rats' familiarity-based stimulus generalization. After surgery, rats were preexposed either to 2 auditory stimuli (A and B) or to only 1 auditory stimulus (B). Following preexposure, all rats received pairings of A and a footshock before assessment of generalized responding (conditioned suppression) to B. Sham rats' generalization was greater when preexposure was to both A and B than when preexposure was to B only. That pattern was abolished in lesioned rats, though no general deficiency was found in other measures of auditory processing. Our findings suggest that the perirhinal cortex is required for rats to encode familiarity as part of stimulus representations.
Citation
Robinson, J., Whitt, E. J., Horsley, R. R., & Jones, P. M. (2010). Familiarity-based stimulus generalization of conditioned suppression in rats is dependent on the perirhinal cortex. Behavioral Neuroscience, 124(5), 587-599. https://doi.org/10.1037/a0020900
Journal Article Type | Article |
---|---|
Publication Date | 2010-10 |
Deposit Date | May 1, 2019 |
Journal | Behavioral Neuroscience |
Print ISSN | 0735-7044 |
Electronic ISSN | 0735-7044 |
Publisher | American Psychological Association |
Peer Reviewed | Peer Reviewed |
Volume | 124 |
Issue | 5 |
Pages | 587-599 |
DOI | https://doi.org/10.1037/a0020900 |
Keywords | Behavioral Neuroscience |
Public URL | https://nottingham-repository.worktribe.com/output/1866366 |
Publisher URL | https://psycnet.apa.org/record/2010-20760-003 |
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