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Familiarity-based stimulus generalization of conditioned suppression in rats is dependent on the perirhinal cortex

Robinson, Jasper; Whitt, Emma J.; Horsley, Rachel R.; Jones, Peter M.

Authors

EMMA WHITT EMMA.WHITT@NOTTINGHAM.AC.UK
Associate Professor

Rachel R. Horsley

Peter M. Jones



Abstract

We report that bilateral, excitoxic lesions of the perirhinal cortex attenuate rats' familiarity-based stimulus generalization. After surgery, rats were preexposed either to 2 auditory stimuli (A and B) or to only 1 auditory stimulus (B). Following preexposure, all rats received pairings of A and a footshock before assessment of generalized responding (conditioned suppression) to B. Sham rats' generalization was greater when preexposure was to both A and B than when preexposure was to B only. That pattern was abolished in lesioned rats, though no general deficiency was found in other measures of auditory processing. Our findings suggest that the perirhinal cortex is required for rats to encode familiarity as part of stimulus representations.

Citation

Robinson, J., Whitt, E. J., Horsley, R. R., & Jones, P. M. (2010). Familiarity-based stimulus generalization of conditioned suppression in rats is dependent on the perirhinal cortex. Behavioral Neuroscience, 124(5), 587-599. https://doi.org/10.1037/a0020900

Journal Article Type Article
Publication Date 2010-10
Deposit Date May 1, 2019
Journal Behavioral Neuroscience
Print ISSN 0735-7044
Electronic ISSN 0735-7044
Publisher American Psychological Association
Peer Reviewed Peer Reviewed
Volume 124
Issue 5
Pages 587-599
DOI https://doi.org/10.1037/a0020900
Keywords Behavioral Neuroscience
Public URL https://nottingham-repository.worktribe.com/output/1866366
Publisher URL https://psycnet.apa.org/record/2010-20760-003