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Adipose-derived mesenchymal stem cells applied in fibrin glue stimulate peripheral nerve regeneration

Masgutov, Ruslan; Masgutova, Galina; Mullakhmetova, Adelya; Zhuravleva, Margarita; Shulman, Anna; Rogozhin, Alexander; Syromiatnikova, Valeriya; Andreeva, Dina; Zeinalova, Alina; Idrisova, Kamilla; Allegrucci, Cinzia; Kiyasov, Andrey; Rizvanov, Albert


Ruslan Masgutov

Galina Masgutova

Adelya Mullakhmetova

Margarita Zhuravleva

Anna Shulman

Alexander Rogozhin

Valeriya Syromiatnikova

Dina Andreeva

Alina Zeinalova

Kamilla Idrisova

Andrey Kiyasov

Albert Rizvanov


Mesenchymal stem cells (MSCs) hold a great promise for cell therapy. To date, they represent one of the best choices for the treatment of post-traumatic injuries of the peripheral nervous system. Although autologous can be easily transplanted in the injured area, clinical advances in this ?led have been impaired by lack of preservation of graft cells into the injury area after transplantation. Indeed, cell viability is not retained after injection into the blood stream, and cells injected directly into the area of injury either are washed off or inhibit regeneration through scar formation and neuroma development. This study proposes a new way of MSCs delivery to the area of traumatic injury by using ?brin glue, which not only ?xes cells at the site of application but also provides extracellular matrix support. Using a sciatic nerve injury model, MSC derived from adipose tissue embedded in ?brin glue were able to enter the nerve and migrate mainly retrogradely after transplantation. They also demonstrated a neuroprotective effect on DRG L5 sensory neurons and stimulated axon growth and myelination. Post-traumatic changes of the sensory neuron phenotype were also improved. Importantly, MSCs stimulated nerve angiogenesis and motor function recovery. Therefore, our data suggest that MSC therapy using ?brin glue is a safe and ef?cient method of cell transplantation in cases of sciatic nerve injury, and that this method of delivery of regeneration stimulants could be bene?cial for the successful treatment of other central and peripheral nervous system conditions.


Masgutov, R., Masgutova, G., Mullakhmetova, A., Zhuravleva, M., Shulman, A., Rogozhin, A., …Rizvanov, A. (2019). Adipose-derived mesenchymal stem cells applied in fibrin glue stimulate peripheral nerve regeneration. Frontiers in Medicine, 6, Article 68.

Journal Article Type Article
Acceptance Date Mar 19, 2019
Online Publication Date Apr 9, 2019
Publication Date Apr 9, 2019
Deposit Date Apr 10, 2019
Publicly Available Date Apr 10, 2019
Journal Frontiers in Medicine
Electronic ISSN 2296-858X
Publisher Frontiers Media
Peer Reviewed Peer Reviewed
Volume 6
Article Number 68
Public URL
Publisher URL


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