Skip to main content

Research Repository

Advanced Search

Microbial-Immune Crosstalk in Elderly-Onset Inflammatory Bowel Disease: Unchartered Territory

Meng, Guanmin; Monaghan, Tanya M.; Duggal, Niharika A.; Tighe, Paddy; Peerani, Farhad

Microbial-Immune Crosstalk in Elderly-Onset Inflammatory Bowel Disease: Unchartered Territory Thumbnail


Authors

Guanmin Meng

TANYA MONAGHAN Tanya.Monaghan@nottingham.ac.uk
Clinical Associate Professor in Luminal Gastroenterology

Niharika A. Duggal

PATRICK TIGHE paddy.tighe@nottingham.ac.uk
Professor of Molecular Immunology

Farhad Peerani



Abstract

Elderly-onset inflammatory bowel disease [IBD] patients exhibit a distinct natural history compared to younger IBD patients, with unique disease phenotypes, differential responses to therapy, and increased surgical morbidity and mortality. Despite the foreseeable high demand for personalized medicine and specialized IBD care in the elderly, current paradigms of IBD management fail to capture the required nuances of care for elderly-onset IBD patients. Our review postulates the roles of systemic and mucosal immunosenescence, inflammageing and a dysbiotic microbial ecosystem in the pathophysiology of elderly-onset IBD. Ultimately, a better understanding of elderly-onset IBD can lead to improved patient outcomes and the tailoring of future preventative and treatment strategies.

Citation

Meng, G., Monaghan, T. M., Duggal, N. A., Tighe, P., & Peerani, F. (2023). Microbial-Immune Crosstalk in Elderly-Onset Inflammatory Bowel Disease: Unchartered Territory. Journal of Crohn's and Colitis, 17(8), 1309-1325. https://doi.org/10.1093/ecco-jcc/jjad025

Journal Article Type Article
Acceptance Date Feb 1, 2023
Online Publication Date Feb 20, 2023
Publication Date 2023-08
Deposit Date Feb 13, 2023
Publicly Available Date Feb 21, 2024
Journal Journal of Crohn's and Colitis
Electronic ISSN 1876-4479
Publisher Oxford University Press (OUP)
Peer Reviewed Peer Reviewed
Volume 17
Issue 8
Article Number jjad025
Pages 1309-1325
DOI https://doi.org/10.1093/ecco-jcc/jjad025
Keywords Inflammatory Bowel Disease, Gut Microbiota, Immunosenescence, Intestinal Barrier Permeability, Inflammaging, Aging
Public URL https://nottingham-repository.worktribe.com/output/17375968
Publisher URL https://academic.oup.com/ecco-jcc/advance-article-abstract/doi/10.1093/ecco-jcc/jjad025/7048942?redirectedFrom=fulltext&login=false
Additional Information This is a pre-copyedited, author-produced version of an article accepted for publication in Journal of Crohn's and Colitis following peer review. The version of record Guanmin Meng, Tanya M Monaghan, Niharika A Duggal, Paddy Tighe, Farhad Peerani, Microbial-Immune Crosstalk in Elderly-Onset Inflammatory Bowel Disease: Unchartered Territory, Journal of Crohn's and Colitis, 2023;, jjad025 is available online at: https://doi.org/10.1093/ecco-jcc/jjad025.

Files




You might also like



Downloadable Citations