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Beneficial effects of fecal microbiota transplantation in recurrent Clostridioides difficile infection

Yadegar, Abbas; Pakpoor, Sepideh F.; Ibrahim, Fathima F.; Nabavi-Rad, Ali; Cook, Laura; Walter, Jens; Seekatz, Anna M.; Wong, Karen; Monaghan, Tanya M.; Kao, Dina

Authors

Abbas Yadegar

Sepideh F. Pakpoor

Fathima F. Ibrahim

Ali Nabavi-Rad

Laura Cook

Jens Walter

Anna M. Seekatz

Karen Wong

TANYA MONAGHAN Tanya.Monaghan@nottingham.ac.uk
Clinical Associate Professor in Luminal Gastroenterology

Dina Kao



Abstract

Fecal microbiota transplantation (FMT) is highly effective in preventing recurrent Clostridioides difficile infection (rCDI). However, the mechanisms underpinning its clinical efficacy are incompletely understood. Herein, we provide an overview of rCDI pathogenesis followed by a discussion of potential mechanisms of action focusing on the current understanding of trans-kingdom microbial, metabolic, immunological, and epigenetic mechanisms. We then outline the current research gaps and offer methodological recommendations for future studies to elevate the quality of research and advance knowledge translation. By combining interventional trials with multiomics technology and host and environmental factors, analyzing longitudinally collected biospecimens will generate results that can be validated with animal and other models. Collectively, this will confirm causality and improve translation, ultimately to develop targeted therapies to replace FMT.

Citation

Yadegar, A., Pakpoor, S. F., Ibrahim, F. F., Nabavi-Rad, A., Cook, L., Walter, J., …Kao, D. (2023). Beneficial effects of fecal microbiota transplantation in recurrent Clostridioides difficile infection. Cell Host and Microbe, 31(5), 695-711. https://doi.org/10.1016/j.chom.2023.03.019

Journal Article Type Review
Acceptance Date Mar 14, 2023
Online Publication Date May 10, 2023
Publication Date May 10, 2023
Deposit Date Mar 25, 2023
Publicly Available Date Mar 29, 2024
Journal Cell Host and Microbe
Print ISSN 1931-3128
Electronic ISSN 1934-6069
Publisher Elsevier BV
Peer Reviewed Peer Reviewed
Volume 31
Issue 5
Pages 695-711
DOI https://doi.org/10.1016/j.chom.2023.03.019
Keywords Recurrent Clostridioides difficile infection; fecal microbiota transplantation; intestinal microbial transfer; host-microbial interactions
Public URL https://nottingham-repository.worktribe.com/output/18850941
Publisher URL https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(23)00124-5

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